The chemistry and biology of ferroptosis Review
| Authors: | Stockwell, B. R.; Jiang, X. |
| Review Title: | The chemistry and biology of ferroptosis |
| Abstract: | Ferroptosis is a recently described form of cell death driven by iron-dependent lipid peroxidation. This type of cell death was first observed in response to treatment of tumor cells with a small-molecule chemical probe named erastin. Most subsequent advances in understanding the mechanisms governing ferroptosis involved the use of genetic screens and small-molecule probes. We describe herein the utility and limitations of chemical probes that have been used to analyze and perturb ferroptosis, as well as mechanistic studies of ferroptosis that benefitted from the use of these probes and genetic screens. We also suggest probes for ferroptosis and highlight mechanistic questions surrounding this form of cell death that will be a high priority for exploration in the future. Copyright © 2020 Elsevier Ltd. All rights reserved. |
| Keywords: | metabolism; cell death; iron; lipid peroxidation; glutathione; cysteine; ros; ferroptosis; cancer; chemical probe |
| Journal Title: | Cell Chemical Biology |
| Volume: | 27 |
| Issue: | 4 |
| ISSN: | 2451-9456 |
| Publisher: | Cell Press |
| Date Published: | 2020-04-16 |
| Start Page: | 365 |
| End Page: | 375 |
| Language: | English |
| DOI: | 10.1016/j.chembiol.2020.03.013 |
| PUBMED: | 32294465 |
| PROVIDER: | scopus |
| PMCID: | PMC7204503 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 1 June 2020 -- Source: Scopus |
