A potential role for apparent diffusion coefficient in the diagnosis of trilateral retinoblastoma Journal Article
| Authors: | Sait, S. F.; Haque, S.; Karimi, S.; Rebeiz, K. J.; Francis, J. H.; Marr, B. P.; Abramson, D. H.; Souweidane, M. M.; Dunkel, I. J. |
| Article Title: | A potential role for apparent diffusion coefficient in the diagnosis of trilateral retinoblastoma |
| Abstract: | We attempted to investigate the potential role for apparent diffusion coefficient (ADC) to diagnose trilateral retinoblastoma (TRb) by retrospectively reviewing brain magnetic resonance images of retinoblastoma patients. Observations: The median ADC measured 620.95 for TRb (n=6) and 1238.5 for normal pineal gland in bilateral retinoblastoma (n=8). Monitoring ADC trends aided in establishing the appropriate diagnoses in 3 patients (2 TRb, 1 benign pineal cyst). Conclusions: Our results provide baseline reference data and describe the importance of downward trending ADC which should prompt consideration of TRb. Unchanged high/nonrestricted values (>1000) may distinguish those with benign pineal tissue and obviate invasive neurosurgical procedures. |
| Keywords: | retinoblastoma; radiology; children; pineoblastoma; diffusion-weighted imaging; diagnostic; pinealoblastoma; large population; mri-based assessment; aged 0-5 years; pineal-gland |
| Journal Title: | Journal of Pediatric Hematology/Oncology |
| Volume: | 42 |
| Issue: | 3 |
| ISSN: | 1077-4114 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 2020-04-01 |
| Start Page: | 238 |
| End Page: | 243 |
| Language: | English |
| ACCESSION: | WOS:000524726900031 |
| DOI: | 10.1097/mph.0000000000001523 |
| PROVIDER: | wos |
| PUBMED: | 31259824 |
| PMCID: | PMC8082522 |
| Notes: | Article -- Source: Wos |
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MSK Authors
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112Marr -
371Dunkel -
256Francis -
114Karimi -
148Haque -
389Abramson -
219Souweidane -
11Rebeiz -
66Farouk Sait
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