Outcomes of benign meningioma in older patients in the United States Journal Article

Authors: Albert, A.; Lee, A.; Thomas, T. V.; Vijayakumar, S.
Article Title: Outcomes of benign meningioma in older patients in the United States
Abstract: Purpose: Older patients have inferior outcomes for meningioma and experience more post-operative complications. The purpose of this study was to identify national treatment patterns and outcomes based on age for benign meningiomas using the National Cancer Database (NCDB). Material and Methods: The NCDB was queried for patients with biopsy-proven World Health Organization Grade (WHO) grade I meningioma diagnosed between 2004 and 2015. Patients were stratified based on age: 18–50, 51–60, 61–70, 71–80, and > 80 years of age. Clinicodemographic details were compared via the Chi Square test. Multivariable logistic regression was used to determine factors associated with receipt of treatment and post-operative complications. Multivariable Cox regression and the Kaplan-Meier method were used to examine survival. Results: 56,960 patients met inclusion criteria with a median follow-up of 48 months. Ages 61–70 (OR 0.73, 95% CI 0.62–0.85, p < .001), ages 71–80 (OR 0.51, 95% CI 0.43–0.60, p < .001), and age > 80 (0.16, 95% CI 0.14–0.19, p < .001) were less likely to receive treatment. Older age groups were associated with increased risk of post-operative complications and post-operative complications predicted for decreased survival. Treatment with surgery (HR 0.57, 95% CI 0.52–0.62, p < .001) and surgery and radiation (HR 0.59, 95% CI 0.50–0.70, p < .001) provided a survival benefit. Older age was associated with a survival decrement. Conclusions: Older patients are less likely to undergo treatment for benign meningioma and are more likely to have post-operative complications. Survival decreased with increasing age. Treatment improved survival among all patients. Risk-benefit ratio of treatment should be carefully considered when treating older patients with benign meningioma. © 2019 Elsevier Inc.
Keywords: radiation; surgery; older patients; benign meningioma
Journal Title: Journal of Geriatric Oncology
Volume: 11
Issue: 4
ISSN: 1879-4068
Publisher: Elsevier Inc.  
Date Published: 2020-05-01
Start Page: 709
End Page: 717
Language: English
DOI: 10.1016/j.jgo.2019.10.017
PUBMED: 31718937
PROVIDER: scopus
Notes: Article -- Export Date: 1 May 2020 -- Source: Scopus
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MSK Authors
  1. Anna Lee
    15 Lee