The Human Tumor Atlas Network: Charting tumor transitions across space and time at single-cell resolution Editorial
| Authors: | Rozenblatt-Rosen, O.; Regev, A.; Oberdoerffer, P.; Nawy, T.; Hupalowska, A.; Rood, J. E.; Ashenberg, O.; Cerami, E.; Coffey, R. J.; Demir, E.; Ding, L.; Esplin, E. D.; Ford, J. M.; Goecks, J.; Ghosh, S.; Gray, J. W.; Guinney, J.; Hanlon, S. E.; Hughes, S. K.; Hwang, E. S.; Iacobuzio-Donahue, C. A.; Jané-Valbuena, J.; Johnson, B. E.; Lau, K. S.; Lively, T.; Mazzilli, S. A.; Pe'er, D.; Santagata, S.; Shalek, A. K.; Schapiro, D.; Snyder, M. P.; Sorger, P. K.; Spira, A. E.; Srivastava, S.; Tan, K.; West, R. B.; Williams, E. H.; and the Human Tumor Atlas Network; Schultz, N.; de Bruijn, I.; Gao, J.; Rudin, C. M.; Hollmann, T.; Massague, J.; Mazutis, L.; Boire, A.; Allaj, V.; Bott, M.; Chan, J. M.; Chaudhary, O.; Chun, J.; Egger, J.; Gan, S.; Gao, V. R.; Hayashi, A.; Laughney, A. M.; Masilionis, I.; Mattar, M.; Offin, M.; Pe'er, I.; Quintanal-Villalonga, A.; Sen, T.; Xie, Y.; Zhang, M. |
| Title: | The Human Tumor Atlas Network: Charting tumor transitions across space and time at single-cell resolution |
| Abstract: | Crucial transitions in cancer—including tumor initiation, local expansion, metastasis, and therapeutic resistance—involve complex interactions between cells within the dynamic tumor ecosystem. Transformative single-cell genomics technologies and spatial multiplex in situ methods now provide an opportunity to interrogate this complexity at unprecedented resolution. The Human Tumor Atlas Network (HTAN), part of the National Cancer Institute (NCI) Cancer Moonshot Initiative, will establish a clinical, experimental, computational, and organizational framework to generate informative and accessible three-dimensional atlases of cancer transitions for a diverse set of tumor types. This effort complements both ongoing efforts to map healthy organs and previous large-scale cancer genomics approaches focused on bulk sequencing at a single point in time. Generating single-cell, multiparametric, longitudinal atlases and integrating them with clinical outcomes should help identify novel predictive biomarkers and features as well as therapeutically relevant cell types, cell states, and cellular interactions across transitions. The resulting tumor atlases should have a profound impact on our understanding of cancer biology and have the potential to improve cancer detection, prevention, and therapeutic discovery for better precision-medicine treatments of cancer patients and those at risk for cancer. The Human Tumor Atlas Network outlines their ambitious plan to generate 3D, single-cell, multiparametric, and longitudinal maps of diverse tumor types. © 2020 |
| Keywords: | sequence analysis; review; cancer patient; cancer diagnosis; cancer prevention; metastasis; cancer research; cell specificity; health care quality; high risk population; tumor; factual database; cell interaction; national health organization; resistance; personalized medicine; tumor microenvironment; data visualization; single cell analysis; clinical outcome; oncological parameters; three-dimensional imaging; human; priority journal; data integration; oncogenomics; ai; cancer moonshot; cancer transitions; human tumor atlas; pre-cancer; single-cell genomics; spatial genomics; spatial imaging; human tumor atlas network; tumor transition |
| Journal Title: | Cell |
| Volume: | 181 |
| Issue: | 2 |
| ISSN: | 0092-8674 |
| Publisher: | Cell Press |
| Date Published: | 2020-04-16 |
| Start Page: | 236 |
| End Page: | 249 |
| Language: | English |
| DOI: | 10.1016/j.cell.2020.03.053 |
| PUBMED: | 32302568 |
| PROVIDER: | scopus |
| PMCID: | PMC7376497 |
| DOI/URL: | |
| Notes: | Review -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
MSK Authors
Related MSK Work