Clinical developments in epigenetic-directed therapies in acute myeloid leukemia Review
| Authors: | Pan, D.; Rampal, R.; Mascarenhas, J. |
| Review Title: | Clinical developments in epigenetic-directed therapies in acute myeloid leukemia |
| Abstract: | Acute myeloid leukemia (AML) is a highly heterogeneous disease arising from acquired genetic and epigenetic aberrations which stifle normal development and differentiation of hematopoietic precursors. Despite the complex and varied biological underpinnings, induction therapy forAMLhas remained fairly uniform over 4 decades and outcomes remain poor for most patients. Recently, enhanced understanding of the leukemic epigenome has resulted in the translational investigation of a number of epigenetic modifying agents currently in various stages of clinical development. These novel therapies are based on mechanistic rationale and offer the potential to improve AML patient outcomes. In light of many recent advances in this field, we provide an updated, clinically oriented review of the evolving landscape of epigenetic modifying agents for the treatment of AML. © 2020 by The American Society of Hematology. |
| Keywords: | cancer chemotherapy; treatment outcome; histone deacetylase inhibitor; neutropenia; review; monotherapy; nonhuman; cytarabine; unindexed drug; anemia; thrombocytopenia; qt prolongation; febrile neutropenia; clinical study; epigenetics; clinical evaluation; daunorubicin; vorinostat; hyperbilirubinemia; idarubicin; panobinostat; romidepsin; azacitidine; belinostat; respiratory failure; mocetinostat; entinostat; dna methyltransferase inhibitor; acute myeloid leukemia; decitabine; tranylcypromine; nivolumab; human; priority journal; bromodomain inhibitor; pinometostat; venetoclax; atezolizumab; guadecitabine; enasidenib; birabresib; ivosidenib; isocitrate dehydrogenase inhibitor; mivebresib; molibresib; olutasidenib; pracinostat; rec 2282 |
| Journal Title: | Blood Advances |
| Volume: | 4 |
| Issue: | 5 |
| ISSN: | 2473-9529 |
| Publisher: | American Society of Hematology |
| Date Published: | 2020-03-01 |
| Start Page: | 970 |
| End Page: | 982 |
| Language: | English |
| DOI: | 10.1182/bloodadvances.2019001245 |
| PUBMED: | 32150613 |
| PROVIDER: | scopus |
| PMCID: | PMC7065485 |
| DOI/URL: | |
| Notes: | Review -- Source: Scopus |
