Hiding in plain sight: Uncovering a new function of vitamin A in redox signaling Journal Article
| Authors: | Hoyos, B.; Acin-Perez, R.; Fischman, D. A.; Manfredi, G.; Hammerling, U. |
| Article Title: | Hiding in plain sight: Uncovering a new function of vitamin A in redox signaling |
| Abstract: | The protein kinase Cδ signalosome modulates the generation of acetyl-Coenzyme A from glycolytic sources. This module is composed of four interlinked components: PKCδ, the signal adapter p66Shc, cytochrome c, and vitamin A. It resides in the intermembrane space of mitochondria, and is at the center of a feedback loop that senses upstream the redox balance between oxidized and reduced cytochrome c as a measure of the workload of the respiratory chain, and transmits a forward signal to the pyruvate dehydrogenase complex to adjust the flux of fuel entering the tricarboxylic acid cycle. The novel role of vitamin A as co-activator and potential electron carrier, required for redox activation of PKCδ, is discussed. This article is part of a Special Issue entitled Retinoid and Lipid Metabolism. |
| Keywords: | signal transduction; review; metabolism; animals; protein serine threonine kinase; protein processing; binding site; aging; feedback system; retinol; mitochondria; mitochondrion; oxidative phosphorylation; oxidation reduction reaction; oxidation-reduction; protein kinase c gamma; protein shc; cytochrome c; energy homeostasis; pyruvate dehydrogenase complex; vitamin a; cytochromes c; protein kinase c-delta; citric acid cycle; electron transport; respiratory chain; acetyl coenzyme a; protein p66; protein kinase c? |
| Journal Title: | Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids |
| Volume: | 1821 |
| Issue: | 1 |
| ISSN: | 1388-1981 |
| Publisher: | Elsevier B.V. |
| Date Published: | 2012-01-01 |
| Start Page: | 241 |
| End Page: | 247 |
| Language: | English |
| DOI: | 10.1016/j.bbalip.2011.06.014 |
| PROVIDER: | scopus |
| PUBMED: | 21763457 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 3 January 2012" - "CODEN: BBMLF" - "Source: Scopus" |
