Immunophenotypic demonstration of two natural killer surface markers, H25 and H366, on fresh human leukemic cells Journal Article

  

Authors:	Körfer, A.; Kirchner, H.; Schneekloth, C.; Bührer, C.; Wisniewski, D.; Gulati, S.; Clarkson, B.; Knowles, R.; Poliwoda, H.; Atzpodien, J.
Article Title:	Immunophenotypic demonstration of two natural killer surface markers, H25 and H366, on fresh human leukemic cells
Abstract:	Using a modified alkaline-phosphatase/antialkaline-phosphatase method for phenotyping fresh human leukemias, we could demonstrate peripheral blood and bone marrow-derived blast cells to specifically react with two monoclonal antibodies (MoAbs), H25 and H366, previously shown to recognize natural killer cells, activated T lymphocytes and a proportion of normal hematopoietic precursor cells. MoAbs H25 and H366 were found to identify the majority of leukemic cells in patients presenting with T-ALL, LGL leukemia, pre-B-ALL, CML, and AML, respectively. © 1989 S. Karger AG, Basel.
Keywords:	leukemia; major clinical study; phenotype; animal; mice; mice, inbred balb c; monoclonal antibody; alkaline phosphatase; antibodies, monoclonal; antigens, neoplasm; immunocytochemistry; cell surface marker; natural killer cell; killer cells, natural; cytochemistry; antigens, surface; natural killer cells; leukemia, myelocytic, acute; leukemia, t-cell, acute; leukemia, myeloid, chronic; leukemia, lymphocytic; leukemia, hairy cell; human; male; female; priority journal; cell surface antigens; antialkaline phosphatase
Journal Title:	Acta Haematologica
Volume:	82
Issue:	4
ISSN:	0001-5792
Publisher:	S. Karger AG
Date Published:	1989-01-01
Start Page:	193
End Page:	196
Language:	English
DOI:	10.1159/000205375
PUBMED:	2511721
PROVIDER:	scopus
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-0024455953&doi=10.1159%2f000205375&partnerID=40&md5=609865e8492bb49d50dc9c3d4b69ab48
Notes:	Article -- Export Date: 14 April 2020 -- Source: Scopus

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