Alveolar soft‐part sarcoma: A clinico‐pathologic study of half a century Journal Article

  


Authors: Lieberman, P. H.; Brennan, M. F.; Kimmel, M.; Erlandson, R. A.; Garin‐Chesa, P.; Flehinger, B. Y.
Article Title: Alveolar soft‐part sarcoma: A clinico‐pathologic study of half a century
Abstract: In the period from 1923 to 1986 our pathologists examined pathologic material from 102 patients with alveolar soft‐part sarcoma (ASPS). Followup clinical data is available for 91. Median followup is 7 years (range 1 month to 27 years). Local recurrence was only found if residual disease was left at the time of the original excision. Survival in those patients who presented without metastases was 77% at 2 years, 60% at 5 years, 38% at 10 years and 15% at 20 years (median 6 years). No survival advantage could be demonstrated for patients who received chemo and/or radiotherapy, although numbers are small and staging not uniform. An evaluation by electron microscopy and immunohistochemistry cannot confirm recent claims that ASPS is a muscle tumor. ASPS is an unusual neoplasm; the primary therapeutic option is aggressive surgical excision. Survival even with the development of metastases can be long. Copyright © 1989 American Cancer Society
Keywords: adolescent; adult; child; aged; child, preschool; major clinical study; follow up; follow-up studies; neoplasm recurrence, local; lung neoplasms; age factors; histology; age; sarcoma; immunoenzyme techniques; histochemistry; soft tissue sarcoma; sex difference; sex factors; ultrastructure; alveolar soft part sarcoma; organelles; middle age; prognosis; human; male; female; priority journal
Journal Title: Cancer
Volume: 63
Issue: 1
ISSN: 0008-543X
Publisher: Wiley Blackwell  
Date Published: 1989-01-01
Start Page: 1
End Page: 13
Language: English
DOI: 10.1002/1097-0142(19890101)63:1<1::Aid-cncr2820630102>3.0.Co;2-e
PUBMED: 2642727
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0024581702&doi=10.1002%2f1097-0142%2819890101%2963%3a1%3c1%3a%3aAID-CNCR2820630102%3e3.0.CO%3b2-E&partnerID=40&md5=0ff9fce074773a3608c84dd1266a167d
Notes: Article -- Source: Scopus
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MSK Authors
  1. Murray F Brennan
    1059 Brennan
  2. Robert A Erlandson
    125 Erlandson
  3. Philip H Lieberman
    42 Lieberman
  4. Pilar Garin-Chesa
    73 Garin-Chesa
  5. Marek Kimmel
    46 Kimmel
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