Benign metastasizing giant cell tumors of bone: A DNA flow cytometric study Journal Article
| Authors: | Ladanyi, M.; Traganos, F.; Huvos, A. G. |
| Article Title: | Benign metastasizing giant cell tumors of bone: A DNA flow cytometric study |
| Abstract: | Approximately 2% of histologically benign giant cell tumors (BGCT) of bone are complicated by lung metastases, which can progress despite their benign histologic appearance. Almost all BGCT studied by DNA flow cytometry (FCM) have been reported to be diploid. However, the very few cases with lung metastases previously analyzed were all aneuploid. To assess the usefulness of DNA FCM in predicting the metastatic potential of BGCT, seven metastasizing BGCT were studied by DNA FCM using paraffin‐embedded tissue. Five were purely diploid, one was tetraploid, and one was aneuploid. The primary and the metastasis showed the same DNA distribution in all but the tetraploid case, in which the metastasis was purely diploid. A single patient, who was in the diploid group, had unresectable tumor in the lungs; she remains alive with stable disease at 30 months. The other six patients, who underwent complete resections of their lung metastases, are free of disease. These results suggest that DNA FCM is not a sensitive method for predicting the metastatic potential of BGCT since most metastasizing cases appear to be diploid. Copyright © 1989 American Cancer Society |
| Keywords: | clinical article; bone neoplasms; bone tumor; flow cytometry; lung neoplasms; histology; age; lung metastasis; dna, neoplasm; metastasis potential; aneuploidy; cytochemistry; giant cell tumor; giant cell tumors; human; male; female; priority journal |
| Journal Title: | Cancer |
| Volume: | 64 |
| Issue: | 7 |
| ISSN: | 0008-543X |
| Publisher: | Wiley Blackwell |
| Date Published: | 1989-10-01 |
| Start Page: | 1521 |
| End Page: | 1526 |
| Language: | English |
| DOI: | 10.1002/1097-0142(19891001)64:7<1521::Aid-cncr2820640727>3.0.Co;2-7 |
| PUBMED: | 2776111 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work