An outline of anti-emetic treatment Journal Article
| Author: | Gralla, R. J. |
| Article Title: | An outline of anti-emetic treatment |
| Abstract: | With the advent of new chemotherapeutic agents, and their well-known side effect of emesis, the need for a greater facility with anti-emetics has emerged. As well as the common problem of chemotherapy-induced emesis, other problems have become apparent such as delayed emesis and anticipatory emesis. The control of such emetic problems may be affected by certain patient characteristics, such as a history of chronic high alcohol intake, and age. Blockade of the different types of neuroreceptors can lead to effective emetic control. Dopamine receptor blockers such as the phenothiazines, butyrophenones and substituted benzamides have been among the most effective agents. However, newer agents, such as ondansetron, which specifically bind to serotonin receptors, may preserve the anti-emetic efficacy of the dopamine-blockers, but without the associated extrapyramidal side effects of these agents. |
| Keywords: | cancer chemotherapy; cisplatin; doxorubicin; conference paper; antineoplastic agent; dacarbazine; vomiting; chlorpromazine; haloperidol; lorazepam; cyclophosphamide; dexamethasone; ondansetron; methylprednisolone; antiemetics; corticosteroid; metoclopramide; droperidol; prochlorperazine; benzodiazepine; diphenhydramine; benzamide derivative; cannabinoid; butyrophenone derivative; dronabinol; phenothiazine derivative; nabilone; human; priority journal |
| Journal Title: | European Journal of Cancer and Clinical Oncology |
| Volume: | 25 |
| Issue: | Suppl. 1 |
| ISSN: | 0277-5379 |
| Publisher: | Elsevier Inc. |
| Date Published: | 1989-01-01 |
| Start Page: | S7 |
| End Page: | S11; discussion S13-S14 |
| Language: | English |
| PUBMED: | 2696642 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Conference Paper -- Export Date: 14 April 2020 -- Source: Scopus |
