Expression of TAG‐72 in normal colon, transitional mucosa, and colon cancer Journal Article

  


Authors: Xu, M.; Real, F. X.; Welt, S.; Schüssler, M. H.; Oettgen, H. F.; Old, L. J.
Article Title: Expression of TAG‐72 in normal colon, transitional mucosa, and colon cancer
Abstract: Monoclonal antibody (MAb) B72.3 detects an epitope carried by high‐molecular‐weight mucins (tumor‐associated glycoprotein, TAG‐72) recently identified as sialyl‐Tn. B72.3 MAb has a restricted pattern of reactivity with normal tissues but it reacts with a high proportion of epithelial cancers. To determine the possible relationship between neoplastic transformation and reactivity with B72.3 MAb, we have analyzed samples of normal colon, colon cancer and transitional mucosa (mucosa adjacent to colorectal cancer) or reactive mucosa (mucosa adjacent to squamous carcinoma of the anal canal, or mucosa overlying lymphoma). B72.3 MAb reacted strongly with 21/21 specimens of transitional mucosa and with 17/21 specimens of adjacent colon cancer. Reactivity of B72.3 MAb with transitional mucosa was strong and homogeneous, whereas reactivity with cancer tissue was weaker and more heterogeneous. Reactive mucosa adjacent to squamous carcinoma or lymphoma was also reactive with B72.3 MAb. Our findings show that, in the colon, expression of TAG‐72 antigen occurs during the process of epithelial cell transformation but is also regulated by factors unrelated to the process of carcinogenesis. Copyright © 1989 Wiley‐Liss, Inc., A Wiley Company
Keywords: human cell; carcinoma, squamous cell; antigen expression; colonic neoplasms; immunoenzyme techniques; antibodies, monoclonal; antigen; colon cancer; lymphoma; histochemistry; colon; antigens, tumor-associated, carbohydrate; epitopes; colon mucosa; intestinal mucosa; normal value; humans; human; priority journal; article
Journal Title: International Journal of Cancer
Volume: 44
Issue: 6
ISSN: 0020-7136
Publisher: John Wiley & Sons  
Date Published: 1989-12-15
Start Page: 985
End Page: 989
Language: English
DOI: 10.1002/ijc.2910440607
PUBMED: 2481651
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0024833858&doi=10.1002%2fijc.2910440607&partnerID=40&md5=afa218adbbedd7dbd77310fea76d5928
Notes: Article -- Export Date: 14 April 2020 -- Source: Scopus
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MSK Authors
  1. Herbert F Oettgen
    130 Oettgen
  2. Lloyd J Old
    593 Old
  3. Sydney Welt
    98 Welt
  4. Francisco X. Real
    42 Real
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