Phase I clinical trial of doxorubicin and iproplatin combination chemotherapy in patients with breast cancer Journal Article

  


Authors: Casper, E. S.; Curley, T.; Hakes, T. B.
Article Title: Phase I clinical trial of doxorubicin and iproplatin combination chemotherapy in patients with breast cancer
Abstract: Forty-eight patients with advanced breast cancer were treated in a disease-specific phase I trial of doxorubicin and iproplatin combination chemotherapy. The doses of doxorubicin ranged between 30 and 50 mg/m2, and the doses of iproplatin ranged between 150 and 250 mg/m2. Myelosuppression was observed at all levels, but was dose-limiting at the highest level. In addition, nausea, diarrhea and malaise were prominent toxicities. Neither cardiac nor renal toxicity was encountered. Nine of 26 (35%) of previously untreated patients, and 5 of 22 (23%) previously treated patients demonstrated partial or complete responses. Although this combination possesses therapeutic activity, given its toxicities, further evaluation of doxorubicin in combination with iproplatin is not recommended. © 1989 Kluwer Academic Publishers.
Keywords: adult; clinical article; aged; doxorubicin; adenocarcinoma; breast cancer; bone marrow suppression; antineoplastic combined chemotherapy protocols; breast neoplasms; blood cell count; phase 1 clinical trial; organoplatinum compounds; intravenous drug administration; middle age; drug evaluation; human; female; priority journal; iproplatin; support, non-u.s. gov't; support, u.s. gov't, p.h.s.
Journal Title: Investigational New Drugs
Volume: 7
Issue: 2-3
ISSN: 0167-6997
Publisher: Springer  
Date Published: 1989-07-01
Start Page: 189
End Page: 193
Language: English
DOI: 10.1007/bf00170856
PUBMED: 2793371
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0024349344&doi=10.1007%2fBF00170856&partnerID=40&md5=5695aa795c3f766cac3138b38bfa2f42
Notes: Article -- Export Date: 14 April 2020 -- Source: Scopus
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MSK Authors
  1. Tracy B Smart-Curley
    70 Smart-Curley
  2. Ephraim S Casper
    108 Casper
  3. Thomas B Hakes
    115 Hakes
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