Flow cytometry as a predictive indicator in patients with operable gastric cancer Journal Article

Authors: Nanus, D. M.; Kelsen, D. P.; Niedzwiecki, D.; Chapman, D.; Brennan, M.; Cheng, E.; Melamed, M.
Article Title: Flow cytometry as a predictive indicator in patients with operable gastric cancer
Abstract: Adenocarcinoma of the proximal portion of the stomach (gastroesophageal [GE] junction and cardia) is increasing in incidence. The inferior survival of patients with GE-cardia lesions as compared with patients with tumors located in the body and antrum has been attributed to anatomic features. To determine if a biological difference could explain the varying prognosis, flow cytometric studies were performed prospectively in 50 patients with operable gastric cancer and analyzed for association with site, histology, gender, age, stage, and disease-free survival. DNA aneuploidy significantly correlated with tumor location: 96% of GE-cardia carcinomas were aneuploid as compared with 48% of body-antrum tumors (P = .0008). Nodal involvement was more common in aneuploid tumors (P = .0548), and women were more likely to have diploid tumors than were men (P = .0233). The median disease-free survival for patients with diploid tumors was 18.5 months as compared with 5.4 months for patients with aneuploid carcinomas (P = .076). Furthermore, within the body-antrum of the stomach, patients with diploid tumors had significantly better disease-free survival than did those with aneuploid tumors from the same site (18.4 v 4.7 months, P = .0185). These results indicate there is a difference in the DNA content of gastric tumors located in different sites within the stomach and that DNA content correlates with prognosis.
Keywords: survival; adult; clinical article; aged; flow cytometry; stomach cancer; aneuploidy; diploidy; prognosis; human; male; female; priority journal
Journal Title: Journal of Clinical Oncology
Volume: 7
Issue: 8
ISSN: 0732-183X
Publisher: American Society of Clinical Oncology  
Date Published: 1989-08-01
Start Page: 1105
End Page: 1112
Language: English
DOI: 10.1200/jco.1989.7.8.1105
PUBMED: 2754450
PROVIDER: scopus
Notes: Article -- Export Date: 14 April 2020 -- Source: Scopus
Citation Impact
MSK Authors
  1. Murray F Brennan
    924 Brennan
  2. David P Kelsen
    435 Kelsen
  3. David M. Nanus
    60 Nanus
  4. Myron Melamed
    53 Melamed
  5. Douglass S. Chapman
    32 Chapman