A unique antigenic epitope of human melanoma is carried on the common melanoma glycoprotein gp95/p97 Journal Article
| Authors: | Furukawa, K. S.; Furukawa, K.; Real, F. X.; Old, L. J.; Lloyd, K. O. |
| Article Title: | A unique antigenic epitope of human melanoma is carried on the common melanoma glycoprotein gp95/p97 |
| Abstract: | Analysis of antibodies present in the serum of melanoma patient FD has shown that they detect a unique tumor epitope present only on the autologous melanoma cell line SK-MEL-131. Previous results had shown that the unique FD epitope is carried on a common glycoprotein of ~90 kD, widely expressed on melanoma and a few other cell types. We now show by sequential radioimmunoprecipitation and partial amino acid sequencing that this common molecule is a previously recognized melanoma antigen, originally identified by mouse mAbs, designated gp95 or p97 (and also known as melanotransferrin). Thus, FD is the first of the class I (unique) melanoma antigens that has been characterized and related to a known cell surface molecule. |
| Keywords: | human cell; nonhuman; animal cell; mouse; melanoma; tumor antigen; cell culture; epitope; glycoprotein; human; priority journal |
| Journal Title: | Journal of Experimental Medicine |
| Volume: | 169 |
| Issue: | 2 |
| ISSN: | 0022-1007 |
| Publisher: | Rockefeller University Press |
| Date Published: | 1989-02-01 |
| Start Page: | 585 |
| End Page: | 590 |
| Language: | English |
| DOI: | 10.1084/jem.169.2.585 |
| PUBMED: | 2463331 |
| PROVIDER: | scopus |
| PMCID: | PMC2189208 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 14 April 2020 -- Source: Scopus |
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