Design of group sequential clinical trials with multiple endpoints Journal Article
| Authors: | Tang, D. I.; Gnecco, C.; Geller, N. L. |
| Article Title: | Design of group sequential clinical trials with multiple endpoints |
| Abstract: | Group sequential testing for randomized clinical trials designed with multiple endpoints is considered. Previously computed tables for single endpoints are still useful, with a change in interpretation of certain parameters. The advantage in setting sample size based on multiple endpoints is that the sample size required when a trial is designed using more than one endpoint is smaller than the sample size based on any single endpoint, if the two calculations are undertaken using matching significance levels and powers. An example is provided, and possible extensions of the work are discussed. © 1989 Taylor & Francis Group, LLC. |
| Keywords: | interim analysis; multiplicity; repeated significance testing; clinical-trial design; o’brien’s statistic |
| Journal Title: | Journal of the American Statistical Association |
| Volume: | 84 |
| Issue: | 407 |
| ISSN: | 0162-1459 |
| Publisher: | American Statistical Association |
| Date Published: | 1989-09-01 |
| Start Page: | 776 |
| End Page: | 779 |
| Language: | English |
| DOI: | 10.1080/01621459.1989.10478836 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 14 April 2020 -- Source: Scopus |
