Clinical use of recombinant human hematopoietic growth factors Journal Article
| Authors: | Laver, J.; Moore, M. A. S. |
| Article Title: | Clinical use of recombinant human hematopoietic growth factors |
| Abstract: | Hematopoletic growth factors comprise a family of hematopoietic regulators with biologic specificities defined by their ability to support proliferation and differentiation of blood cells of different lineages. The biologic specificities of these factors are highly complex, dose dependent, and frequently overlapping. Recent advances In the cloning of hematopoietlc growth factor genes and the availability of recombinant material have led investigators to conduct clinical trials with these agents. Some of these factors have been studied and used In chemotherapy-induced neutropeala, myelodysplastic syndromes, and bone marrow failure syndromes. In this paper, we review the experience with growth factors that have been tested and that currently are being introduced in clinical trials. In addition, we report some factors with possible future interest for clinicians and researchers. [J Nati Cancer Inst 81:1370-1382, 1989]. © 1989 Oxford University Press. |
| Keywords: | cancer chemotherapy; leukemia; antianemic agent; review; neoplasms; interleukin 2; erythropoietin; anemia; leukopenia; granulocyte macrophage colony stimulating factor; interleukin 1beta; interleukin 4; interleukin 5; interleukin 7; cytokine; myelodysplastic syndrome; genetic engineering; recombinant proteins; hematopoietic stem cells; interleukin 6; acquired immunodeficiency syndrome; drug therapy; bone marrow transplantation; interleukin 1alpha; granulocyte colony stimulating factor; clinical trials; colony stimulating factor 1; growth substances; leukemia inhibitory factor; interleukin 3; anemia, aplastic; human; priority journal; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; hematopoietic cell growth factors |
| Journal Title: | JNCI: Journal of the National Cancer Institute |
| Volume: | 81 |
| Issue: | 18 |
| ISSN: | 0027-8874 |
| Publisher: | Oxford University Press |
| Date Published: | 1989-09-20 |
| Start Page: | 1370 |
| End Page: | 1382 |
| Language: | English |
| DOI: | 10.1093/jnci/81.18.1370 |
| PUBMED: | 2674457 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Review -- Export Date: 14 April 2020 -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work