Five novel cell surface antigens of CNS neoplasms Journal Article
| Authors: | Jennings, M. T.; Jennings, V. D. L.; Asadourian, L. L. H.; Rosenblum, M.; Albino, A. P.; Cairncross, J. G.; Old, L. J. |
| Article Title: | Five novel cell surface antigens of CNS neoplasms |
| Abstract: | Optimal monoclonal antibody-mediated immunotherapy requires the identification of tumor-restricted cell surface antigens. We have identified and partially characterized 5 new monoclonal antibodies generated against malignant astrocytoma, medulloblastoma, neuroblastoma and melanoma which were used to define 5 neuroectodermal tumor antigenic systems. CNT 1 identifies a 57-kDa, heat-stable, trypsin-sensitive neuroblastoma surface antigen, which is expressed intracellularly in many malignant gliomas, medulloblastomas, ependymomas, breast and ovarian carcinomas. CNT 2 reacts with a 130-kDa, heat-labile, trypsin- and neuraminidase-resistant antigen restricted to low-grade astrocytomas and malignant gliomas. CNT 11 reacts with a 70-kDa, heat-labile, trypsin-sensitive antigen coded for by a gene on chromosome 12, and is restricted to astrocytomas, neuroblastomas and sarcomas. CNT 8 identifies a heat-labile, trypsin-sensitive antigen whose gene has been localized to chromosome 15 and is expressed by neuroectodermal and mesodermally derived tumors and few epithelial cancers. The B2.6 antigen is identified only in terms of serologic reactivity with a subset of cultured astrocytomas and melanomas. Neuroectodermal tumor-associated antigens may be categorized as lineage-consistent, lineage-independent and putatively tumor-restricted in their expression. These restricted antibodies may be potentially useful reagents to consider for monoclonal antibody-mediated immunotherapy of CNS neoplasms. © 1989. |
| Keywords: | immunohistochemistry; human cell; glioma; neoplasm; cell line; tumor cells, cultured; monoclonal antibody; membrane antigen; antibodies, monoclonal; antigen; immunotherapy; antigens, neoplasm; cell culture; neuroblastoma; radioisotope; molecular weight; neuroectoderm tumor; neuroectodermal tumor; human; priority journal; support, non-u.s. gov't; support, u.s. gov't, p.h.s. |
| Journal Title: | Journal of the Neurological Sciences |
| Volume: | 89 |
| Issue: | 1 |
| ISSN: | 0022-510X |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 1989-01-01 |
| Start Page: | 63 |
| End Page: | 78 |
| Language: | English |
| DOI: | 10.1016/0022-510x(89)90007-5 |
| PUBMED: | 2926443 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 14 April 2020 -- Source: Scopus |
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