MRI for breast cancer screening, diagnosis, and treatment Journal Article
| Authors: | Morrow, M.; Waters, J.; Morris, E. |
| Article Title: | MRI for breast cancer screening, diagnosis, and treatment |
| Abstract: | MRI is used widely both for screening women who are at increased risk of breast cancer and for treatment selection. Prospective studies confirm that MRI screening of women with known or suspected genetic mutation results in a higher sensitivity for cancer detection than does mammography. However, survival data are not available. In women with breast cancer, MRI detects cancer not identified with other types of screening. In two randomised trials, this increased sensitivity did not translate into improved selection of surgical treatment or a reduction in the number of operations. Data for longer-term outcomes such as ipsilateral breast tumour recurrence rates and contralateral breast cancer incidence are scarce, but to date do not show clear benefit for MRI. MRI is better than other methods of assessing the response to neoadjuvant chemotherapy, and is helpful in identifying the primary tumour in patients who present with axillary adenopathy. © 2011 Elsevier Ltd. |
| Keywords: | gene mutation; mutation; cancer recurrence; cytotoxic agent; cancer risk; systemic therapy; cancer adjuvant therapy; cancer patient; nuclear magnetic resonance imaging; magnetic resonance imaging; cancer diagnosis; cancer incidence; lymphatic metastasis; diagnostic accuracy; sensitivity and specificity; breast cancer; mastectomy; cancer screening; breast neoplasms; brca1 protein; prediction; cost effectiveness analysis; health care cost; mammography; neoplasm, residual; genes, brca1; family history; lymph node; echography; cancer size; partial mastectomy; reoperation; tamoxifen; intermethod comparison; high risk population; axilla; intraductal carcinoma; occult cancer; meta analysis (topic); comparative effectiveness; ipsilateral breast tumour recurrence |
| Journal Title: | Lancet |
| Volume: | 378 |
| Issue: | 9805 |
| ISSN: | 0140-6736 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 2011-11-19 |
| Start Page: | 1804 |
| End Page: | 1811 |
| Language: | English |
| DOI: | 10.1016/s0140-6736(11)61350-0 |
| PROVIDER: | scopus |
| PUBMED: | 22098853 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 3 January 2012" - "CODEN: LANCA" - "Source: Scopus" |
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