An animal model of epidural compression of the spinal cord Journal Article

  


Authors: Arbit, E.; Galicich, W.; Galicich, J. H.; Lau, N.
Article Title: An animal model of epidural compression of the spinal cord
Abstract: A new model of subacute compression of the spinal cord is described. Using an expanding epidural mass, a gradual, progressive, and highly reproducible neurological deficit was induced in rats over a 7-day period, resulting in paraplegia. Studies of spinal cord edema, disruption of the blood-spinal cord barrier, and somatosensory evoked responses, as well a histopathological and microangiographical studies, revealed a marked similarity to changes produced in other spinal compression models and in humans. The model may serve to answer some fundamental questions regarding the pathophysiology and efficacy of various treatment modalities of spinal cord compression.
Keywords: nonhuman; biological model; animal experiment; mammal; spinal cord compression; spinal cord tumor; spine metastasis; evoked somatosensory response; female; priority journal
Journal Title: Neurosurgery
Volume: 24
Issue: 6
ISSN: 0148-396X
Publisher: Wolters Kluwer  
Date Published: 1989-06-01
Start Page: 860
End Page: 863; discussion 863
Language: English
DOI: 10.1227/00006123-198906000-00011
PUBMED: 2747860
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0024344608&doi=10.1227%2f00006123-198906000-00011&partnerID=40&md5=55309c84af676c6955fdc32906c50c55
Notes: Article -- Export Date: 14 April 2020 -- Source: Scopus
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MSK Authors
  1. Nancy Lau
    8 Lau
  2. Ehud Arbit
    66 Arbit
  3. Joseph Galicich
    53 Galicich
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