C-1‘-branched acyclovir derivatives. Synthesis and antiviral evaluation Journal Article
| Authors: | Seheiner, P.; Geer, A.; Bucknor, A. M.; Gadler, H.; Price, R. W. |
| Article Title: | C-1‘-branched acyclovir derivatives. Synthesis and antiviral evaluation |
| Abstract: | The synthesis of 9-[1-(2-hydroxyethoxy)-3- (3a), its thia-congener (3b) and prodrugs (4a,b) was accomplished by paths involving Michael-type addition. The new compounds were found to be inactive against herpes simplex type 1 (HSV-1) and type 2 (HSV-2), human cytomegalovirus (CMV) and varicella-zoster virus (VZV), and unreactive as substrates for HSV-1 thymidine kinase phosphorylation. © 1989, Taylor & Francis Group, LLC. All rights reserved. |
| Keywords: | nonhuman; aciclovir; herpes simplex; drug screening; drug synthesis; thymidine kinase; herpes; nuclear magnetic resonance; cytomegalovirus; aciclovir derivative; varicella zoster virus; article; human herpesvirus 3 |
| Journal Title: | Nucleosides & Nucleotides |
| Volume: | 8 |
| Issue: | 8 |
| ISSN: | 0732-8311 |
| Publisher: | Taylor & Francis Inc. |
| Date Published: | 1989-01-01 |
| Start Page: | 1441 |
| End Page: | 1451 |
| Language: | English |
| DOI: | 10.1080/07328318908048852 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 14 April 2020 -- Source: Scopus |
