Synthesis and evaluation of 2', 3'-dideoxy-9-deazaadenosine and some related derivatives Conference Paper
| Authors: | Tam, S.; Holman, M.; Klein, R. S.; Mitsuya, M.; Broder, S. |
| Title: | Synthesis and evaluation of 2', 3'-dideoxy-9-deazaadenosine and some related derivatives |
| Conference Title: | 8th International Round Table on Nucleosides, Nucleotides, and Their Biological Applications |
| Abstract: | In this paper we report the synthesis of 2'.3'-dideoxy-9-cleazaadenosine (2) and the., corresponding 2'rated-and 3'-deoxy-analogs, 6 and 8. These -nucleosides are very stable towards acid and thus overcome one of the main drawbacks of 2'3'-dideoxy-purine-nucleosides, such as the antiviral agent 2'3, -dideoxyadenosine (ddA). However, evaluation of these compounds and some related 2'-deoxy derivatives (10–14) in the antiviral assay for the human immunodeficiency virus has revealed no significant activity. © 1989, Taylor & Francis Group, LLC. All rights reserved. |
| Keywords: | unclassified drug; methodology; drug synthesis; cell culture; antiviral activity; human immunodeficiency virus 1; 2',3' dideoxy 9 deazaadenosine; 2',3' dideoxy 9 deazaadenosine derivative |
| Journal Title | Nucleosides & Nucleotides |
| Volume: | 8 |
| Issue: | 5-6 |
| Conference Dates: | 1988 Oct 2-5 |
| Conference Location: | Orange Beach, AL |
| ISBN: | 0732-8311 |
| Publisher: | Taylor & Francis Inc. |
| Date Published: | 1989-01-01 |
| Start Page: | 1109 |
| End Page: | 1110 |
| Language: | English |
| DOI: | 10.1080/07328318908054300 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 14 April 2020 -- Source: Scopus |
