Inhibition of cell growth and macromolecule biosynthesis of human promyelocytic leukemic cells by acridone alkaloids Journal Article
| Authors: | Chou, T. C.; Tzeng, C. C.; Wu, T. S.; Watanabe, K. A.; Su, T. L. |
| Article Title: | Inhibition of cell growth and macromolecule biosynthesis of human promyelocytic leukemic cells by acridone alkaloids |
| Abstract: | Acridone alkaloids of plants indigenous to the Orient were isolated and purified, and their chemical structures were determined. A total of 50 acridones and their synthetic derivatives were subjected to rapid screening for inhibition of macromolecular synthesis using radiolabeled precursors of DNA, RNA and protein. These compounds were then studied to examine cell growth inhibition of human promyelocytic leukemic cells (HL‐60). Cytotoxicity was studied using the trypan blue exclusion method. Of 50 compounds evaluated for cell growth inhibition, 12 compounds showed IC50<10 μM; 12 compounds, 10‐20 μM; 8 compounds, 20‐100 μM; and 18 compounds, >100 μM. Copyright © 1989 John Wiley & Sons, Ltd. |
| Keywords: | unclassified drug; human cell; dna synthesis; cell growth; structure activity relation; cell culture; protein synthesis; rna synthesis; screening; promyelocytic leukemia; drug isolation; growth inhibition; alkaloid; cell strain hl 60; human; article; nucleic acid synthesis; acridone derivative; achronycine; acridone alkaloids; biochemical effect; human leukemic cells; acronine derivative; pyrano[3,2 b]acridone derivative |
| Journal Title: | Phytotherapy Research |
| Volume: | 3 |
| Issue: | 6 |
| ISSN: | 0951-418X |
| Publisher: | John Wiley & Sons |
| Date Published: | 1989-01-01 |
| Start Page: | 237 |
| End Page: | 242 |
| Language: | English |
| DOI: | 10.1002/ptr.2650030604 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 14 April 2020 -- Source: Scopus |
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