Studies on the DNA elongation inhibitor and its proliferating cell nuclear antigen-dependent control in simian virus 40 DNA replication in vitro Journal Article
| Authors: | Lee, S. H.; Kwong, A. D.; Ishimi, Y.; Hurwitz, J. |
| Article Title: | Studies on the DNA elongation inhibitor and its proliferating cell nuclear antigen-dependent control in simian virus 40 DNA replication in vitro |
| Abstract: | A 120-kDa protein that blocks DNA termini has been purified from extracts of HeLa cells. This protein inhibits the action of a number of enzymes that catalyze reactions involving the 5' and 3' ends of DNA (DNA ligase, 3' and 5' exonucleases, and DNA polymerase α). The 120-kDa protein blocks the synthesis of long DNA chains that are normally formed during simian virus 40 DNA replication, causing the accumulation of small DNA fragments. The effects of this protein can be reversed by the addition of proliferating cell nuclear antigen and other protein fractions (activators). |
| Keywords: | dna replication; hela cell; cell culture; protein purification; simian virus 40; cycline; virus dna; simiae; simian virus; human; priority journal |
| Journal Title: | Proceedings of the National Academy of Sciences of the United States of America |
| Volume: | 86 |
| Issue: | 13 |
| ISSN: | 0027-8424 |
| Publisher: | National Academy of Sciences |
| Date Published: | 1989-07-01 |
| Start Page: | 4877 |
| End Page: | 4881 |
| Language: | English |
| DOI: | 10.1073/pnas.86.13.4877 |
| PUBMED: | 2567992 |
| PROVIDER: | scopus |
| PMCID: | PMC297518 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 14 April 2020 -- Source: Scopus |
