Single dose versus hyperfractionated total body irradiation before allogeneic bone marrow transplantation: A non-randomized comparative study of 54 patients at the Institut Gustave-Roussy Journal Article
| Authors: | Cosset, J. M.; Baume, D.; Pico, J. L.; Shank, B.; Girinski, T.; Benhamou, E.; Briot, E.; Malaise, E.; Hayat, M.; Dutreix, J. |
| Article Title: | Single dose versus hyperfractionated total body irradiation before allogeneic bone marrow transplantation: A non-randomized comparative study of 54 patients at the Institut Gustave-Roussy |
| Abstract: | At the Institut Gustave-Roussy (IGR), from January 1982 to December 1986, 54 patients received total body irradiation (TBI) as a part of the conditioning regimen before allogeneic bone marrow transplantation. The patients were non-randomly assigned to either single dose TBI (STBI) (31 patients receiving 10 Gy at a 4.5 cGy/min dose rate, 8 Gy to the lungs) or to a hyperfractionated scheme (HTBI) (23 patients receiving 13.2 Gy in 11 fractions, 3 fractions per day, 9 Gy to the lungs). Relapse rate and overall survival were not significantly different in the two STBI and HTBI groups, in spite of a larger number of 2nd and 3rd remission patients in the HTBI subset. The incidence of interstitial pneumonitis (IP) was significantly reduced in the HTBI group (13%, versus 45% after STBI, p = 0.02). Lethality by IP was also lower after HTBI (4%, versus 26% after STBI, p = 0.08). There was no case of venoocclusive disease of the liver in the HTBI group, whereas three cases were observed after STBI. Based on these results, the IGR activated, in January 1987, a randomized trial comparing the single dose 10 Gy TBI (8 Gy to the lung) to a new hyperfractionated schedule (11 fractions of 1.35 Gy, 3 fractions per day, 9 Gy to the lungs). © 1989. |
| Keywords: | adolescent; adult; child; controlled study; leukemia; major clinical study; clinical trial; comparative study; combined modality therapy; cytarabine; methotrexate; methodology; randomized controlled trial; radiotherapy dosage; cyclophosphamide; melphalan; whole body radiation; radiation dose fractionation; graft rejection; drug therapy; cyclosporin a; bone marrow transplantation; graft vs host disease; whole-body irradiation; total body irradiation; human; male; female; priority journal; fractionation in radiotherapy |
| Journal Title: | Radiotherapy and Oncology |
| Volume: | 15 |
| Issue: | 2 |
| ISSN: | 0167-8140 |
| Publisher: | Elsevier Inc. |
| Date Published: | 1989-06-01 |
| Start Page: | 151 |
| End Page: | 160 |
| Language: | English |
| DOI: | 10.1016/0167-8140(89)90129-1 |
| PUBMED: | 2669036 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 14 April 2020 -- Source: Scopus |
