RNA targets of wild-type and mutant FET family proteins Journal Article
| Authors: | Hoell, J. I.; Larsson, E.; Runge, S.; Nusbaum, J. D.; Duggimpudi, S.; Farazi, T. A.; Hafner, M.; Borkhardt, A.; Sander, C.; Tuschl, T. |
| Article Title: | RNA targets of wild-type and mutant FET family proteins |
| Abstract: | FUS, EWSR1 and TAF15, constituting the FET protein family, are abundant, highly conserved RNA-binding proteins with important roles in oncogenesis and neuronal disease, yet their RNA targets and recognition elements are unknown. Using PAR-CLIP, we defined global RNA targets for all human FET proteins and two ALS-causing human FUS mutants. FET members showed similar binding profiles, whereas FUS mutants showed a drastically altered binding pattern, consistent with changes in subcellular localization. © 2011 Nature America, Inc. All rights reserved. |
| Keywords: | unclassified drug; mutation; mutant protein; wild type; rna binding protein; rna-binding proteins; rna, messenger; sequence alignment; cellular distribution; base sequence; binding sites; protein family; protein ewsr1; calmodulin-binding proteins; sequence analysis, dna; protein rna binding; rna-binding protein fus; hek293 cells; protein fus; protein taf15; amyotrophic lateral sclerosis; tata-binding protein associated factors; protein fet |
| Journal Title: | Nature Structural and Molecular Biology |
| Volume: | 18 |
| Issue: | 12 |
| ISSN: | 1545-9993 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2011-11-13 |
| Start Page: | 1428 |
| End Page: | 1431 |
| Language: | English |
| DOI: | 10.1038/nsmb.2163 |
| PROVIDER: | scopus |
| PMCID: | PMC3230689 |
| PUBMED: | 22081015 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 3 January 2012" - "CODEN: NSMBC" - "Source: Scopus" |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work