Risk factors by molecular subtypes of breast cancer across a population-based study of women 56 years or younger Journal Article
| Authors: | Gaudet, M. M.; Press, M. F.; Haile, R. W.; Lynch, C. F.; Glaser, S. L.; Schildkraut, J.; Gammon, M. D.; Thompson, W. D.; Bernstein, J. L. |
| Article Title: | Risk factors by molecular subtypes of breast cancer across a population-based study of women 56 years or younger |
| Abstract: | Differences in incidence, prognosis, and treatment response suggest gene expression patterns may discern breast cancer subtypes with unique risk factor profiles; however, previous results were based predominantly on older women. In this study, we examined similar relationships in women ≤56 years, classified by immunohistochemical staining for estrogen receptor, progesterone receptor, and human epidermal growth factor receptor-2 for 890 breast cancer cases and 3,432 frequency-matched population-based controls. Odds ratios (OR) and 95% confidence intervals (CI) for tumor subtypes were calculated using multivariate polytomous regression models. A total of 455 (51.1%) tumors were considered luminal A, 72 (8.1%) luminal B, 117 (13.1%) non-luminal HER-2/neu+, and 246 (27.6%) triple negative. Triple negative tumors were associated with breast feeding duration (per 6 months: OR = 0.76, 95% CI 0.64-0.90). Among premenopausal women, increasing body size was more strongly associated with luminal B (OR = 1.73, 95% CI 1.07-2.77) and triple negative tumors (OR = 1.67, 95% CI 1.22-2.28). A history of benign breast disease was associated only with increased risk of luminal A tumors (OR = 1.89, 95% CI 1.43-2.50). A family history of breast cancer was a risk factor for luminal A tumors (OR = 1.93, 95% CI 1.38-2.70) regardless of age, and triple negative tumors with higher risks for women<45 (OR = 5.02, 95% CI 2.82-8.92; P for age interaction = 0.005). We found that little-to-no breastfeeding and high BMI were associated with increased risk of triple negative breast cancer. That some risk factors differ by molecular subtypes suggests etiologic heterogeneity in breast carcinogenesis among young women. © Springer Science+Business Media, LLC. 2011. |
| Keywords: | immunohistochemistry; adult; controlled study; human tissue; middle aged; young adult; major clinical study; case-control studies; cancer risk; endometrium cancer; ovary cancer; breast cancer; epidermal growth factor receptor 2; risk factors; breast neoplasms; risk factor; carcinogenesis; body mass index; multicenter study; family history; receptor, erbb-2; receptors, estrogen; receptors, progesterone; body size; multivariate analysis; estrogen receptor; progesterone receptor; intraductal carcinoma; her2; carcinoma, ductal, breast; population based case control study; medullary carcinoma; triple negative breast cancer; breast feeding |
| Journal Title: | Breast Cancer Research and Treatment |
| Volume: | 130 |
| Issue: | 2 |
| ISSN: | 0167-6806 |
| Publisher: | Springer |
| Date Published: | 2011-11-01 |
| Start Page: | 587 |
| End Page: | 597 |
| Language: | English |
| DOI: | 10.1007/s10549-011-1616-x |
| PROVIDER: | scopus |
| PUBMED: | 21667121 |
| PMCID: | PMC3721192 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 3 January 2012" - "CODEN: BCTRD" - "Source: Scopus" |
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