Getting into position: Nuclear movement in muscle cells Review
| Authors: | Azevedo, M.; Baylies, M. K. |
| Review Title: | Getting into position: Nuclear movement in muscle cells |
| Abstract: | The positioning of nuclei within the cell is a dynamic process that depends on the cell's fate and developmental stage and that is adjusted for optimal cell function. This is especially true in skeletal muscle cells, which contain hundreds of myonuclei distributed evenly along the periphery of the muscle cell. Mispositioned myonuclei are often associated with muscle dysfunction and disease. Different mechanisms governing myonuclear positioning are now emerging, with several of the new genes implicated in nuclear movement linked to human muscle disease. Here we discuss the recent advances in myonuclear positioning and its implications for muscle size and function from the view of Drosophila. Additionally, we highlight similarities and differences to mammalian systems and provide connections to human muscle disease. © 2020 Elsevier Ltd |
| Keywords: | review; nonhuman; drosophila; cytoplasm; muscle disease; cytoskeleton; skeletal muscle; myoblast; muscle; muscle function; muscle cell; muscle development; cell surface; musculoskeletal system parameters; cell spreading; muscle size; nuclear positioning; priority journal; myofilament; linc complex |
| Journal Title: | Trends in Cell Biology |
| Volume: | 30 |
| Issue: | 4 |
| ISSN: | 0962-8924 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2020-04-01 |
| Start Page: | 303 |
| End Page: | 316 |
| Language: | English |
| DOI: | 10.1016/j.tcb.2020.01.002 |
| PUBMED: | 32008895 |
| PROVIDER: | scopus |
| PMCID: | PMC7131867 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 1 April 2020 -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work