Hybrid therapy for spinal metastases Review

  


Authors: Rothrock, R.; Pennington, Z.; Ehresman, J.; Bilsky, M. H.; Barzilai, O.; Szerlip, N. J.; Sciubba, D. M.
Review Title: Hybrid therapy for spinal metastases
Abstract: The combination of separation surgery and stereotactic body radiotherapy optimizes the treatment of metastatic spine tumors. The integration of SBRT into treatment paradigms produces superb local control rates and consequently has diminished the role of surgery from principle treatment to one of adjuvant therapy. Under this paradigm, hybrid therapy for the treatment of metastatic spine tumors employs separation surgery to decompress the spinal cord and stabilize the spine while creating a safe target for ablative SBRT. Hybrid therapy is well tolerated, allows an early return to systemic therapy, and provides durable, local tumor control compared with more aggressive traditional approaches. © 2019 Elsevier Inc.
Keywords: treatment outcome; surgical technique; overall survival; review; cancer recurrence; postoperative care; neurosurgery; treatment indication; radiation; practice guideline; postoperative complication; spinal cord; radiosurgery; spinal cord compression; spine; brachytherapy; radiosensitivity; clinical decision making; stereotactic radiosurgery; cancer control; metastases; tumor; stereotactic body radiation therapy; spinal cord metastasis; intraoperative radiotherapy; spinal cord decompression; patient simulation; reconstructive surgery; human; priority journal; separation surgery; hybrid therapy
Journal Title: Neurosurgery Clinics of North America
Volume: 31
Issue: 2
ISSN: 1042-3680
Publisher: W.B. Saunders Co-Elsevier Inc.  
Date Published: 2020-04-01
Start Page: 191
End Page: 200
Language: English
DOI: 10.1016/j.nec.2019.11.001
PUBMED: 32147010
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078342596&doi=10.1016%2fj.nec.2019.11.001&partnerID=40&md5=cc77158def9f01703c14773abd376a25
Notes: Review -- Export Date: 1 April 2020 -- Source: Scopus
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MSK Authors
  1. Mark H Bilsky
    319 Bilsky
  2. Ori Barzilai
    73 Barzilai
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