The association between social support and chemotherapy-related toxicity in older patients with cancer Journal Article
| Authors: | Shahrokni, A.; Sun, C. L.; Tew, W. P.; Mohile, S. G.; Ma, H.; Owusu, C.; Klepin, H. D.; Gross, C. P.; Lichtman, S. M.; Gajra, A.; Katheria, V.; Cohen, H. J.; Hurria, A. |
| Article Title: | The association between social support and chemotherapy-related toxicity in older patients with cancer |
| Abstract: | Objectives: The goal of this study was to evaluate the relationship between social support (SS) and grade 3–5 chemotherapy-related toxicities among older adults with cancer. Methods: This is a secondary analysis of a prospective longitudinal study of patients aged 65+ with solid cancer which led to the development of a predictive model for grade 3–5 chemotherapy-related toxicity (the Cancer and Aging Research Group [CARG] Chemotherapy Toxicity Risk Score). SS was measured by a modified version of Medical-Outcome Study-Social Support Survey and grade 3–5 hematological and non-hematological toxicities were captured and graded using CTCAE version 3.0. Patients were categorized into those with poor (SS score ≤ 75) and good SS (score of 76–100). Multivariate polychotomous logistic regression was used to examine the associations between SS and chemotherapy-related toxicity with adjustment for the CARG Toxicity Risk Score. Results: Compared to patients with good SS, those with poor SS were less likely to have grade 3–5 toxicity, especially for non-hematological toxicity (adjusted OR = 0.52, p = .02). Patients who did not have someone to take them to the doctor “most” or “all of the time” were less likely to have grade 3–5 non-hematological toxicity compared to patients who had someone to take them to the doctor most or all of the time (adjusted OR = 0.32, p = .02). Conclusion: Our study showed that patients with poor SS, especially those with less availability of someone to take them to doctors were less likely to have a documented grade 3–5 non-hematological toxicity. © 2019 Elsevier Inc. |
| Keywords: | cancer chemotherapy; cancer survival; controlled study; aged; major clinical study; overall survival; cancer patient; comparative study; prospective study; blood toxicity; lung cancer; combination chemotherapy; risk assessment; digestive system cancer; social support; adverse outcome; clinical evaluation; toxicity; longitudinal study; female genital tract cancer; chemotherapy toxicity; human; male; female; priority journal; article; older adults with cancer |
| Journal Title: | Journal of Geriatric Oncology |
| Volume: | 11 |
| Issue: | 2 |
| ISSN: | 1879-4068 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2020-03-01 |
| Start Page: | 274 |
| End Page: | 279 |
| Language: | English |
| DOI: | 10.1016/j.jgo.2019.08.015 |
| PUBMED: | 31501014 |
| PROVIDER: | scopus |
| PMCID: | PMC7054161 |
| DOI/URL: | |
| Notes: | Article -- Source: Scopus |
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