Association of preoperative biliary drainage technique with postoperative outcomes among patients with resectable hepatobiliary malignancy Journal Article


Authors: Hu, Q. L.; Liu, J. B.; Ellis, R. J.; Liu, J. Y.; Yang, A. D.; D'Angelica, M. I.; Ko, C. Y.; Merkow, R. P.
Article Title: Association of preoperative biliary drainage technique with postoperative outcomes among patients with resectable hepatobiliary malignancy
Abstract: Background: Endoscopic biliary stenting (EBS) and percutaneous transhepatic biliary drainage (PTBD) are two techniques used for preoperative biliary drainage prior to hepatobiliary resection. The objectives of this study were to determine predictors of the drainage technique selection and to evaluate the association between drainage technique and postoperative outcomes. Methods: Using ACS NSQIP data (2014–2017), patients who underwent preoperative biliary drainage prior to hepatobiliary resection for malignancy were identified. Separate multivariable-adjusted, propensity score (PS) adjusted, and PS matched logistic regression models were constructed to evaluate the association between drainage technique and postoperative outcomes. Results: Of 527 patients identified, 431 (81.8%) received EBS and 96 (18.2%) received PTBD. Patients who underwent PTBD had more preoperative co-morbidities, including higher ASA class, recent weight loss, and hypoalbuminemia (all p < 0.05). After multivariable adjustment, PTBD was significantly associated with 30-day DSM (OR 1.92, 95% CI 1.24–2.97, p = 0.004), overall SSI (OR 1.74, 95% CI 1.10–2.76, p = 0.019), and superficial SSI (OR 2.08, 95% CI 1.20–3.60, p = 0.010). These findings remained significant for both PS-adjusted and PS-matched models. Conclusion: Patients undergoing hepatobiliary resection selected for PTBD had significantly more preoperative co-morbidities and nutritional deficits. Compared to EBS, PTBD was associated with significantly higher odds of postoperative morbidity and mortality. © 2019 International Hepato-Pancreato-Biliary Association Inc.
Keywords: adult; controlled study; middle aged; major clinical study; postoperative period; ascites; morbidity; cohort analysis; retrospective study; age; hypoalbuminemia; liver failure; length of stay; preoperative period; bile leakage; endoscopic surgery; reoperation; surgical infection; comorbidity; sepsis; surgical mortality; hospital readmission; biliary tract drainage; nutritional deficiency; clinical outcome; hepatobiliary system cancer; body weight loss; renal replacement therapy; human; male; female; article
Journal Title: HPB
Volume: 22
Issue: 2
ISSN: 1365-182X
Publisher: Elsevier Science, Inc.  
Date Published: 2020-02-01
Start Page: 249
End Page: 257
Language: English
DOI: 10.1016/j.hpb.2019.06.011
PUBMED: 31350104
PROVIDER: scopus
PMCID: PMC8319720
DOI/URL:
Notes: Article -- Source: Scopus
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