Reconstructing the evolutionary history of multiple myeloma Review
| Authors: | Maura, F.; Rustad, E. H.; Boyle, E. M.; Morgan, G. J. |
| Review Title: | Reconstructing the evolutionary history of multiple myeloma |
| Abstract: | Multiple myeloma is the second most common lymphoproliferative disorder, characterized by aberrant expansion of monoclonal plasma cells. In the last years, thanks to novel next generation sequencing technologies, multiple myeloma has emerged as one of the most complex hematological cancers, shaped over time by the activity of multiple mutational processes and by the acquisition of key driver events. In this review, we describe how whole genome sequencing is emerging as a key technology to decipher this complexity at every stage of myeloma development: precursors, diagnosis and relapsed/refractory. Defining the time windows when driver events are acquired improves our understanding of cancer etiology and paves the way for early diagnosis and ultimately prevention. © 2020 Elsevier Ltd |
| Keywords: | cancer survival; gene mutation; single nucleotide polymorphism; review; cancer patient; disease association; multiple myeloma; early diagnosis; tumor growth; personalized medicine; cancer prognosis; high throughput sequencing; human; priority journal; whole genome sequencing; timing; whole exome sequencing; driver events |
| Journal Title: | Best Practice and Research: Clinical Haematology |
| Volume: | 33 |
| Issue: | 1 |
| ISSN: | 1521-6926 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2020-03-01 |
| Start Page: | 101145 |
| Language: | English |
| DOI: | 10.1016/j.beha.2020.101145 |
| PUBMED: | 32139011 |
| PROVIDER: | scopus |
| PMCID: | PMC7389821 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 1 April 2020 -- Source: Scopus |
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