Systematic review of patient-reported outcomes following surgical treatment of lymphedema Review

Authors: Coriddi, M.; Dayan, J.; Sobti, N.; Nash, D.; Goldberg, J.; Klassen, A.; Pusic, A.; Mehrara, B.
Review Title: Systematic review of patient-reported outcomes following surgical treatment of lymphedema
Abstract: Introduction: Analysis of quality of life (QOL) outcomes is an important aspect of lymphedema treatment since this disease can substantially impact QOL in affected individuals. There are a growing number of studies reporting patient-reported outcomes (PROMs) for patients with lymphedema. The purpose of this study was to conduct a systematic review of outcomes and utilization of PROMs following surgical treatment of lymphedema. Methods: A literature search of four databases was performed up to and including March, 2019. Studies included reported on QOL outcomes after physiologic procedures, defined as either lymphovenous bypass (LVB) or vascularized lymph node transplant (VLNT), to treat upper and/or lower extremity primary or secondary lymphedema. Results: In total, 850 studies were screened—of which, 32 studies were included in this review. Lymphovenous bypass was the surgical intervention in 16 studies, VLNT in 11 studies, and both in 5 studies. Of the 32 total studies, 16 used validated survey tools. The most commonly used PROM was the lymph quality of life measure for limb lymphedema (LYMQOL) (12 studies). In the remaining four studies, the upper limb lymphedema 27 scale (ULL27), the short form 36 questionnaire (SF-36), the lymphedema functioning, disability and health questionnaire (Lymph-ICF), and lymphedema life impact scale (LLIS) were each used once. QOL improvement following surgical treatment was noted in all studies. Conclusions: Physiologic surgical treatment of lymphedema results in improved QOL outcomes in most patients. The use of validated PROM tools is increasing but there is no current consensus on use. Future research to evaluate the psychometric properties of PROMs in lymphedema is needed to guide the development and use of lymphedema-specific tools. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.
Keywords: treatment outcome; surgical technique; review; quality of life; transplantation; lymphedema; systematic review; rating scale; patient-reported outcomes; short form 36; deep inferior epigastric perforator flap; superficial inferior epigastric artery flap; skin graft; liposuction; lymphovenous anastomosis; patient-reported outcome; human; lymphovenous bypass; vascularized lymph node transplant; lymph node transplant; lymph quality of life measure for limb lymphedema; lymphedema functioning disability and health questionnaire; lymphedema life impact scale; upper limb lymphedema 27 scale
Journal Title: Cancers
Volume: 12
Issue: 3
ISSN: 2072-6694
Publisher: MDPI  
Date Published: 2020-03-01
Start Page: 565
Language: English
DOI: 10.3390/cancers12030565
PROVIDER: scopus
PUBMED: 32121343
Notes: Review -- Source: Scopus
Citation Impact
MSK Authors
  1. Babak Mehrara
    307 Mehrara
  2. Joseph Henry Dayan
    40 Dayan
  3. Michelle Renee Coriddi
    13 Coriddi