Clinical benefits of a multivariate prediction model for bladder cancer: A decision analytic approach Journal Article

Authors: Vickers, A. J.; Cronin, A. M.; Kattan, M. W.; Gonen, M.; Scardino, P. T.; Milowsky, M. I.; Dalbagni, G.; Bochner, B. H.
Article Title: Clinical benefits of a multivariate prediction model for bladder cancer: A decision analytic approach
Abstract: BACKGROUND: It has been demonstrated that multivariate prediction models predict cancer outcomes more accurately than cancer stage; however, the effects of these models on clinical management are unclear. The objective of the current study was to determine whether a previously published multivariate prediction model for bladder cancer ("bladder nomogram") improved medical decision making when referral for adjuvant chemotherapy was used as a model. METHODS: Data were analyzed from an international cohort study of 4462 patients who underwent cystectomy without chemotherapy from 1969 to 2004. The number of patients eligible for chemotherapy was determined using pathologic stage criteria (lymph node-positive disease or pathologic T3 [pT3] or pT4 tumor classification) and for 3 cutoff levels on the bladder nomogram (10%, 25%, and 70% risk of recurrence with surgery alone). The number of recurrences was calculated by applying a relative risk reduction to the baseline risk among eligible patients. Clinical net benefit was then calculated by combining recurrences and treatments and weighting the latter by a factor related to drug tolerability. RESULTS: A nomogram cutoff outperformed pathologic stage for chemotherapy in every scenario of drug effectiveness and tolerability. For a drug with a relative risk of 0.80, with which clinicians would treat ≤20 patients to prevent 1 recurrence, use of the nomogram was equivalent to a strategy that resulted in 60 fewer chemotherapy treatments per 1000 patients without any increase in recurrence rates. CONCLUSIONS: The authors concluded that referring patients who undergo cystectomy to adjuvant chemotherapy on the basis of a multivariate model is likely to lead to better patient outcomes than the use of pathologic stage. Further research is warranted to evaluate the clinical effects of multivariate prediction models. © 2009 American Cancer Society.
Keywords: adult; treatment outcome; aged; middle aged; major clinical study; drug tolerability; drug efficacy; cancer adjuvant therapy; cancer patient; chemotherapy, adjuvant; cancer staging; recurrence risk; lymph node metastasis; antineoplastic agent; sensitivity and specificity; medical decision making; cohort analysis; bladder cancer; urinary bladder neoplasms; risk; nomograms; adjuvant chemotherapy; cystectomy; forecasting; multivariate analysis; risk reduction; decision making; statistical model; outcomes; nomogram; patient referral; decision support
Journal Title: Cancer
Volume: 115
Issue: 23
ISSN: 0008-543X
Publisher: Wiley Blackwell  
Date Published: 2009-01-12
Start Page: 5460
End Page: 5469
Language: English
DOI: 10.1002/cncr.24615
PUBMED: 19823979
PROVIDER: scopus
PMCID: PMC2785133
Notes: --- - "Cited By (since 1996): 4" - "Export Date: 30 November 2010" - "CODEN: CANCA" - "Source: Scopus"
Altmetric Score
MSK Authors
  1. Guido Dalbagni
    250 Dalbagni
  2. Peter T Scardino
    621 Scardino
  3. Mithat Gonen
    701 Gonen
  4. Andrew J Vickers
    556 Vickers
  5. Angel M Cronin
    145 Cronin
  6. Bernard Bochner
    324 Bochner