Mycosis fungoides in pediatric patients: Clinical features, diagnostic challenges, and advances in therapeutic management Review


Authors: Wu, J. H.; Cohen, B. A.; Sweren, R. J.
Review Title: Mycosis fungoides in pediatric patients: Clinical features, diagnostic challenges, and advances in therapeutic management
Abstract: Mycosis fungoides (MF) is the most common primary cutaneous lymphoma in pediatric patients. Given the indolent nature of MF, symptoms often present in childhood but may not be diagnosed as MF until adulthood. Delayed diagnosis is associated with poor long-term prognosis. Thus, increased clinician recognition and accurate diagnosis of early-stage MF in pediatric patients is critically important. In this review, we summarize the clinical features of the most common pediatric MF subtypes and highlight important differences between pediatric and adult MF. Moreover, we reviewed all pediatric MF case series published between 2008 and 2018 to analyze treatment modalities and identify emerging therapies. As treatment of pediatric MF is complex, selection of therapy varies significantly depending upon the specific clinical characteristics, disease severity, and patients' preferences. Ā© 2019 Wiley Periodicals, Inc.
Keywords: cancer chemotherapy; child; clinical feature; review; cancer diagnosis; childhood cancer; cancer control; mycosis fungoides; therapy; topical treatment; adult disease; phototherapy; pediatric patients; cancer prognosis; human; priority journal; topical agent
Journal Title: Pediatric Dermatology
Volume: 37
Issue: 1
ISSN: 0736-8046
Publisher: Blackwell Scientific Publications  
Date Published: 2020-01-01
Start Page: 18
End Page: 28
Language: English
DOI: 10.1111/pde.14026
PUBMED: 31630432
PROVIDER: scopus
DOI/URL:
Notes: Review -- Source: Scopus
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  1. Julie Wu
    2 Wu