Synapse - Adult human glioblastomas harbor radial glia-like cells

Adult human glioblastomas harbor radial glia-like cells Journal Article

Authors:	Wang, R.; Sharma, R.; Shen, X.; Laughney, A. M.; Funato, K.; Clark, P. J.; Shpokayte, M.; Morgenstern, P.; Navare, M.; Xu, Y.; Harbi, S.; Masilionis, I.; Nanjangud, G.; Yang, Y.; Duran-Rehbein, G.; Hemberg, M.; Pe'er, D.; Tabar, V.
Article Title:	Adult human glioblastomas harbor radial glia-like cells
Abstract:	Tabar and colleagues report that adult brain tumors comprise neoplastic radial glia-like cells reminiscent of normal radial glia of early development. They are responsive to inflammation signals and may represent putative stem cells of origin of this lethal tumor. © 2020 The Authors Radial glia (RG) cells are the first neural stem cells to appear during embryonic development. Adult human glioblastomas harbor a subpopulation of RG-like cells with typical RG morphology and markers. The cells exhibit the classic and unique mitotic behavior of normal RG in a cell-autonomous manner. Single-cell RNA sequencing analyses of glioblastoma cells reveal transcriptionally dynamic clusters of RG-like cells that share the profiles of normal human fetal radial glia and that reside in quiescent and cycling states. Functional assays show a role for interleukin in triggering exit from dormancy into active cycling, suggesting a role for inflammation in tumor progression. These data are consistent with the possibility of persistence of RG into adulthood and their involvement in tumor initiation or maintenance. They also provide a putative cellular basis for the persistence of normal developmental programs in adult tumors. © 2020 The Authors
Keywords:	immunohistochemistry; adult; controlled study; nonhuman; brain tumor; cell proliferation; mitosis; mouse; cell division; animal experiment; animal model; inflammation; daughter cell; in vivo study; neural stem cell; subventricular zone; tumor cell culture; glioblastoma; cell cycle m phase; tumor growth; rna sequence; tumor microenvironment; cancer stem cells; single cell analysis; radial glia; human; male; female; priority journal; article; stem cell self-renewal; scrnaseq; tumor mitosis; dissociated cell culture
Journal Title:	Stem Cell Reports
Volume:	14
Issue:	2
ISSN:	2213-6711
Publisher:	Cell Press
Date Published:	2020-02-11
Start Page:	338
End Page:	350
Language:	English
DOI:	10.1016/j.stemcr.2020.01.007
PUBMED:	32004492
PROVIDER:	scopus
PMCID:	PMC7014025
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078775920&doi=10.1016%2fj.stemcr.2020.01.007&partnerID=40&md5=6551629ab70272ee216894c8230cc40d
Notes:	Article -- Source: Scopus