Evaluating clonal hematopoiesis in tumor-infiltrating leukocytes in breast cancer and secondary hematologic malignancies Journal Article

   

Authors:	Comen, E. A.; Bowman, R. L.; Selenica, P.; Kleppe, M.; Farnoud, N. R.; Pareja, F.; Weigelt, B.; Hill, C. E.; Alon, A.; Geyer, F. C.; Akturk, G.; Reis-Filho, J. S.; Norton, L.; Levine, R. L.
Article Title:	Evaluating clonal hematopoiesis in tumor-infiltrating leukocytes in breast cancer and secondary hematologic malignancies
Abstract:	Chemotherapy and radiation therapy are the foundations of adjuvant therapy for early-stage breast cancer. As a complication of cytotoxic regimens, breast cancer patients are at risk for therapy-related myeloid neoplasms (t-MNs). These t-MNs are commonly refractory to antileukemic therapies and result in poor patient outcomes. We previously demonstrated that somatic mutations in leukemia-related genes are present in the tumor-infiltrating leukocytes (TILeuks) of a subset of early breast cancers. Here, we performed genomic analysis of microdissected breast cancer tumor cells and TILeuks from seven breast cancer patients who subsequently developed leukemia. In four patients, mutations present in the leukemia were detected in breast cancer TILeuks. This finding suggests that TILeuks in the primary breast cancer may harbor the ancestor of the future leukemogenic clone. Additional research is warranted to ascertain whether infiltrating mutant TILeuks could constitute a biomarker for the development of t-MN and to determine the functional consequences of mutant TILeuks. © The Author(s) 2019. Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oup.com.
Journal Title:	JNCI: Journal of the National Cancer Institute
Volume:	112
Issue:	1
ISSN:	0027-8874
Publisher:	Oxford University Press
Date Published:	2020-01-01
Start Page:	107
End Page:	110
Language:	English
DOI:	10.1093/jnci/djz157
PUBMED:	31504684
PROVIDER:	scopus
PMCID:	PMC7690564
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078505957&doi=10.1093%2fjnci%2fdjz157&partnerID=40&md5=0285f90fd122a91bd6975271616eff10
Notes:	Article -- Export Date: 2 March 2020 -- Source: Scopus

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