Evaluation of the 12-gene molecular score and the 21-gene recurrence score as predictors of response to neo-adjuvant chemotherapy in estrogen receptor-positive, HER2-negative breast cancer Journal Article
| Authors: | Soliman, H.; Wagner, S.; Flake, D. D. 2nd; Robson, M.; Schwartzberg, L.; Sharma, P.; Magliocco, A.; Kronenwett, R.; Lancaster, J. M.; Lanchbury, J. S.; Gutin, A.; Gradishar, W. |
| Article Title: | Evaluation of the 12-gene molecular score and the 21-gene recurrence score as predictors of response to neo-adjuvant chemotherapy in estrogen receptor-positive, HER2-negative breast cancer |
| Abstract: | Background: Neo-adjuvant chemotherapy (NaCT) facilitates complete surgical resection in locally advanced breast cancer. Due to its association with improved outcome, complete pathologic response (pCR) to neo-adjuvant treatment has been accepted as a surrogate for long-term outcome in clinical trials of human epidermal growth factor receptor 2 (HER2)-positive, triple-negative, or luminal B breast cancer patients. In contrast, NaCT is effective in only ~ 7–10% of estrogen receptor (ER)-positive, HER2-negative disease. Response biomarkers would enable such patients to be selected for NaCT. Methods: Two commercially available breast cancer prognostic signatures [12-gene molecular score (MS) and the 21-gene Recurrence Score (RS)] were compared in their ability to predict pCR to NaCT in ER-positive, HER2-negative breast cancer in six public RNA expression microarray data sets. Scores were approximated according to published algorithms and analyzed by logistic regression. Results: Expression data were available for 764 ER-positive, HER2-negative breast cancer samples, including 59 patients with pCR. The two scores were well correlated. Either score was a significant predictor of pCR (12-gene MS p = 9.4 × 10−5; 21-gene RS p = 0.0041). However, in a model containing both scores, the 12-gene MS remained significant (p = 0.0079), while the 21-gene RS did not (p = 0.79). Conclusions: In this microarray study, two commercial breast cancer prognostic scores were significant predictors of response to NaCT. In direct comparison, the 12-gene MS outperformed the 21-gene RS as a predictive marker for NaCT. Considering pCR as surrogate for improved survival, these results support the ability of both scores to predict chemotherapy sensitivity. © 2020, The Author(s). |
| Keywords: | cancer chemotherapy; treatment response; unclassified drug; major clinical study; doxorubicin; fluorouracil; cancer combination chemotherapy; paclitaxel; protein bcl 2; gene expression; epidermal growth factor receptor 2; protein; cyclophosphamide; docetaxel; microarray analysis; celecoxib; intermethod comparison; epirubicin; neoadjuvant chemotherapy; taxane derivative; anthracycline; ixabepilone; aurora a kinase; cd68 antigen; glutathione transferase m1; estrogen receptor alpha; cancer prognosis; estrogen receptor positive breast cancer; bag1 protein; human; article; evaluation study; stromelysin 3; prognostic assessment; growth factor receptor bound protein 7; 21 gene recurrence score; human epidermal growth factor receptor 2 negative breast cancer; azgp1 protein; birc5 protein; ccnb1 protein; ctsl2 protein; dhcr7 protein; il6st protein; mgp protein; rbbp8 protein; stc2 protein; ube2c protein; 12 gene molecular score |
| Journal Title: | Annals of Surgical Oncology |
| Volume: | 27 |
| Issue: | 3 |
| ISSN: | 1068-9265 |
| Publisher: | Springer |
| Date Published: | 2020-03-01 |
| Start Page: | 765 |
| End Page: | 771 |
| Language: | English |
| DOI: | 10.1245/s10434-019-08039-7 |
| PUBMED: | 31907749 |
| PROVIDER: | scopus |
| PMCID: | PMC7000508 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 2 March 2020 -- Source: Scopus |
