Microbial agents to treat cancer Book Section
| Author: | Redelman-Sidi, G. |
| Editor: | Schmidt, T. |
| Article/Chapter Title: | Microbial agents to treat cancer |
| Abstract: | Microbes have been used to treat cancer since the late 19th century. The first microbial treatment of cancer were Coley’s toxins. These were followed by the introduction, in the 1970s, of Mycobacterium bovis BCG, as a treatment for bladder cancer. In the past two decades, concomitant with the expansion of the field of cancer immunotherapy, there has been increased interest in using microbial agents to treat cancer. Talimogene laherparepvec (T-VEC) is the first microbial agent since BCG to gain approval as a cancer therapy. Other microbial agents, including Salmonella typhimurium, Clostridium novyi, Listeria monocytogenes, and several oncolytic viruses, are in various stages of clinical investigation. Multiple other microbial agents are in preclinical stages of investigation. Herein, I will review the current state of microbial treatment of cancer. © 2019 Elsevier Inc. All rights reserved. |
| Keywords: | immunotherapy; vaccinia; adenovirus; oncolytic; bcg; clostridium; salmonella; viral; bacterial; microbial; toxoplasma; talimogene laherparepvec; cancer; listeria |
| Book Title: | Encyclopedia of Microbiology. 4th ed |
| ISBN: | 9780128117378 |
| Publisher: | Elsevier Inc. |
| Publication Place: | Amsterdam, Netherlands |
| Date Published: | 2019-01-01 |
| Start Page: | 103 |
| End Page: | 109 |
| Language: | English |
| DOI: | 10.1016/b978-0-12-801238-3.64159-4 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Book Chapter -- Volume 3 -- Export Date: 2 March 2020 -- Source: Scopus |
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