Are we accurately evaluating depression in patients with cancer? Journal Article


Authors: Saracino, R. M.; Aytürk, E.; Cham, H.; Rosenfeld, B.; Feuerstahler, L. M.; Nelson, C. J.
Article Title: Are we accurately evaluating depression in patients with cancer?
Abstract: Depression remains poorly managed in oncology, in part because of the difficulty of reliably screening and assessing for depression in the context of medical illness. Whether somatic items really skew the ability to identify true" depression, or represent meaningful indicators of depression, remains to be determined. This study utilized item response theory (IRT) to compare the performance of traditional depression criteria with Endicott's substitutive criteria (ESC; tearfulness or depressed appearance; social withdrawal; brooding; cannot be cheered up). The Patient Health Questionnaire (PHQ-9), ESC, and Center for Epidemiologic Studies Depression Scale (CES-D) were administered to 558 outpatients with cancer. IRT models were utilized to evaluate global and item fit for traditional PHQ-9 items compared with a modified version replacing the 4 somatic items with ESC. The modified PHQ-9 ESC scale was the best fit using a partial credit model; model fit was improved after collapsing the middle 2 response categories and removing psychomotor agitation/retardation. This improved model showed satisfactory scale precision and internal consistency, and was free from differential item functioning for gender, age, and race. Concurrent and criterion validity were supported. Thus, as many have speculated. utilizing the ESC may result in more accurate identification of depressive symptoms in oncology. Depressed mood, anhedonia, and suicidal ideation retained their expected properties in the modified scale, indicating that the traditional underlying syndrome of depression likely remains the same, but the ESC may provide more specificity when assessing patients with cancer.
Keywords: prevalence; oncology; depression; screening; anxiety; model; performance; people; severity; diagnostic criteria; fit indexes; somatic symptoms; phq-9; irt
Journal Title: Psychological Assessment
Volume: 32
Issue: 1
ISSN: 1040-3590
Publisher: American Psychological Association  
Date Published: 2020-01-01
Start Page: 98
End Page: 107
Language: English
ACCESSION: WOS:000504011400010
DOI: 10.1037/pas0000765
PROVIDER: wos
PMCID: PMC6928435
PUBMED: 31393150
Notes: Source: Wos
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  1. Christian Nelson
    392 Nelson
  2. Rebecca Mary James
    79 James