Maitake mushroom (Grifola frondosa): Systematic review by the natural standard research collaboration Journal Article
| Authors: | Ulbricht, C.; Weissner, W.; Basch, E.; Giese, N.; Hammerness, P.; Rusie-Seamon, E.; Varghese, M.; Woods, J. |
| Article Title: | Maitake mushroom (Grifola frondosa): Systematic review by the natural standard research collaboration |
| Abstract: | The objective of this study was to evaluate the scientific evidence on maitake, including expert opinion, folkloric precedent, history, pharmacology, kinetics/dynamics, interactions, adverse effects, toxicology, and dosing. This review serves as a clinical support tool. Electronic searches were conducted in 10 databases, 20 additional journals (not indexed in common databases), and bibliographies from 50 selected secondary references. No restrictions were placed on the language or quality of the publications. All literature collected pertained to efficacy in humans, dosing, precautions, adverse effects, use in pregnancy and lactation, interactions, alteration of laboratory assays, and mechanisms of action. Standardized inclusion and exclusion criteria were used for selection. Grades were assigned using an evidence-based grading rationale. There was a lack of systematic study on the safety and effectiveness of maitake in humans. However, based on popular use and supportive scientific data, three indications are discussed in this review: cancer, diabetes, and immunostimulation. Despite the lack of scientific evidence, maitake mushroom remains a popular agent in commercial products. Future randomized controlled trials are warranted. © 2009 BC Decker Inc. |
| Keywords: | leukemia; unclassified drug; review; hepatitis; drug efficacy; drug potentiation; drug safety; hypertension; nonhuman; alpha interferon; human immunodeficiency virus infection; antineoplastic agent; evidence based medicine; neoplasm; neoplasms; animal; animals; breast cancer; interleukin 12p70; interleukin 4; lung cancer; tumor regression; drug hypersensitivity; chemistry; drug research; gamma interferon; drug mechanism; systematic review; laboratory test; arthritis; diabetes mellitus; stomach cancer; mitomycin c; pregnancy; cytokine production; liver cancer; medical literature; immunological adjuvant; antidiabetic agent; antihypertensive agent; food drug interaction; food-drug interactions; chinese medicine; immunostimulation; mushroom; virus infection; traditional medicine; hypercholesterolemia; corticosteroid; beta glucan; natural product; adjuvants, immunologic; maitake; grifola frondosa extract; grifola frondosa; grifola; drug utilization; bacterial infection; mycosis; chickenpox; immunosuppressive agent; pharmacology; beta-glucan; beta-glucans; lactation; bone cancer; cell strain hepg2; drug indication; interactions; herbs and supplements; interleukin 18; allergic pneumonitis; bibliographic database; snakebite; verruca vulgaris |
| Journal Title: | Journal of the Society for Integrative Oncology |
| Volume: | 7 |
| Issue: | 2 |
| ISSN: | 1715-894X |
| Publisher: | BC Decker |
| Date Published: | 2009-03-01 |
| Start Page: | 66 |
| End Page: | 72 |
| Language: | English |
| DOI: | 10.2310/7200.2009.0007 |
| PUBMED: | 19476741 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Export Date: 30 November 2010" - "Source: Scopus" |
