Kidney tubular toxicity of maintenance pemetrexed therapy Journal Article
| Authors: | Glezerman, I. G.; Pietanza, M. C.; Miller, V.; Seshan, S. V. |
| Article Title: | Kidney tubular toxicity of maintenance pemetrexed therapy |
| Abstract: | Pemetrexed is an antifolate agent approved for the treatment of advanced lung cancer. Major side effects include myelosuppression and neutropenia. Three patients developed kidney disease while being treated with maintenance pemetrexed. Kidney biopsy specimens showed tubulointerstitial injury with tubular simplification, shrinkage, loss of brush border, and tubular atrophy in a more advanced case. Kidney function remained impaired, but stable, after discontinuation of pemetrexed therapy in all cases. Am J Kidney Dis. 58(5):817-820. (C) 2011 by the National Kidney Foundation, Inc. |
| Keywords: | nephrotoxicity; pemetrexed; patient; cell lung-cancer; phase-i; antifolate; tubulointerstitial injury; nephrogenic diabetes-insipidus; folate homeostasis |
| Journal Title: | American Journal of Kidney Diseases |
| Volume: | 58 |
| Issue: | 5 |
| ISSN: | 0272-6386 |
| Publisher: | W.B. Saunders Co. |
| Date Published: | 2011-11-01 |
| Start Page: | 817 |
| End Page: | 820 |
| Language: | English |
| ACCESSION: | WOS:000296385700020 |
| DOI: | 10.1053/j.ajkd.2011.04.030 |
| PROVIDER: | wos |
| PUBMED: | 21849225 |
| Notes: | --- - Article - "Source: Wos" |
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