Immunotherapy for acute myeloid leukemia: From allogeneic stem cell transplant to novel therapeutics Review

   


Authors: Knorr, D. A.; Goldberg, A. D.; Stein, E. M.; Tallman, M. S.
Review Title: Immunotherapy for acute myeloid leukemia: From allogeneic stem cell transplant to novel therapeutics
Abstract: Immunotherapy in the form of allogeneic stem cell transplantation (SCT) plays an instrumental role in the treatment of acute myeloid leukemia (AML), with non-transplant modalities of immunotherapy including checkpoint blockade now being actively explored. Here, we provide an overview of the graft versus leukemia (GVL) effect in AML as a window into understanding the prospects of AML immunotherapy. We explore the roles of various cell types in orchestrating anti-leukemic immunity, as well as those contributing to the unique immune suppressive state of myeloid diseases. We discuss specific approaches to engage the immune system, while noting the challenges of the AML antigen landscape and the barriers to immune modulation. We review the potential for immunomodulatory agents in combination with cellular therapies, donor lymphocyte infusion, and following SCT. Finally, to address the challenge of minimal residual disease (MRD) following chemotherapy, we propose combination epigenetic and immunotherapy for the eradication of MRD. © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group.
Keywords: allogeneic stem cell transplantation; review; nonhuman; t cells; cancer immunotherapy; immune response; immunotherapy; minimal residual disease; epigenetics; antibodies; humoral immunity; azacitidine; vaccines; aml; acute myeloid leukemia; checkpoint blockade; decitabine; human; priority journal; neoantigen; antineoplastic monoclonal antibody
Journal Title: Leukemia and Lymphoma
Volume: 60
Issue: 14
ISSN: 1042-8194
Publisher: Taylor & Francis Group  
Date Published: 2019-01-01
Start Page: 3350
End Page: 3362
Language: English
DOI: 10.1080/10428194.2019.1639167
PUBMED: 31335250
PROVIDER: scopus
PMCID: PMC6928392
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85077072151&doi=10.1080%2f10428194.2019.1639167&partnerID=40&md5=a66b0707a7796f1e255611a171dd26ab
Notes: Review -- Source: Scopus
Altmetric
What is Altmetric?
Citation Impact
What is Dimensions Citation Badge?
BMJ Impact Analytics
MSK Authors
  1. Eytan Moshe Stein
    342 Stein
  2. Martin Stuart Tallman
    649 Tallman
  3. Aaron David Goldberg
    106 Goldberg
  4. David A Knorr
    21 Knorr
Related MSK Work