Absence of structural alterations of the multidrug resistance genes in transitional cell carcinoma Journal Article

  


Authors: Klein, E. A.; Allen, G.; Fair, W. R.; Reuter, V.; Chaganti, R. S. K.
Article Title: Absence of structural alterations of the multidrug resistance genes in transitional cell carcinoma
Abstract: Tumor DNA from 27 patients with treated or untreated transitional cell carcinomas of the urinary tract was screened for genomic alterations of the multidrug resistance genes in order to determine whether structural changes of these genes are important in primary urothelial tumors. None of the tumors showed evidence of amplification or rearrangements of either mdr1 or mdr2. The lack of amplification or rearrangements observed in these tumors suggests that structural alterations of the mdr1 and mdr2 genes are not important mediators of drug resistance in TCC. © 1990 Springer-Verlag.
Keywords: clinical article; gene amplification; drug resistance; urologic neoplasms; gene rearrangement; genetic engineering; dna, neoplasm; carcinoma, transitional cell; transitional cell carcinoma; urinary tract carcinoma; dna probes; blotting, southern; human; article; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; multidrug resistance genes
Journal Title: Urological Research
Volume: 18
Issue: 4
ISSN: 0300-5623
Publisher: Springer  
Date Published: 1990-07-01
Start Page: 281
End Page: 286
Language: English
DOI: 10.1007/bf00294774
PUBMED: 2219592
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0025167994&doi=10.1007%2fBF00294774&partnerID=40&md5=67030083e158bc132eb2be484ca5ca05
Notes: Article -- Export Date: 27 January 2020 -- Source: Scopus
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MSK Authors
  1. Victor Reuter
    1224 Reuter
  2. Raju S K Chaganti
    391 Chaganti
  3. William R Fair
    342 Fair
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