Neoadjuvant chemotherapy and surgery of cancer of the esophagus Journal Article
| Authors: | Kelsen, D. P.; Bains, M.; Burt, M. |
| Article Title: | Neoadjuvant chemotherapy and surgery of cancer of the esophagus |
| Abstract: | Neoadjuvant, or pre‐operative, chemotherapy for esophageal cancer has become an area of increasing interest because of the failure of conventional therapy (surgery or radiation) to improve disease‐free or overall survival. Several autopsy series have demonstrated that, in many symptomatic Western patients, esophageal cancer is a systemic disease. Neoadjuvant chemotherapy thus, in theory, allows a simultaneous attack on both the primary and metastatic disease. A number of single‐arm, phase II multi‐modality trials have been completed. Toxicities of chemotherapy, while substantial, have been tolerable. With careful attention to detail, operative morbidity and mortality has not been increased. Large‐scale randomized trials, needed to evaluate the impact of this technique on disease‐free and overall survival, have been designed and will shortly be activated. Copyright © 1990 Wiley‐Liss, Inc., A Wiley Company |
| Keywords: | adult; aged; major clinical study; review; carcinoma, squamous cell; cisplatin; fluorouracil; combined modality therapy; antineoplastic combined chemotherapy protocols; bleomycin; mitomycin; esophagus cancer; vinblastine sulfate; esophageal neoplasms; esophageal cancer; mitoguazone; drug evaluation; preoperative chemotherapy; human; multi‐modality treatment; pre‐operative chemotherapy |
| Journal Title: | Seminars in Surgical Oncology |
| Volume: | 6 |
| Issue: | 5 |
| ISSN: | 8756-0437 |
| Publisher: | John Wiley & Sons |
| Date Published: | 1990-01-01 |
| Start Page: | 268 |
| End Page: | 273 |
| Language: | English |
| DOI: | 10.1002/ssu.2980060508 |
| PUBMED: | 2237085 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 27 January 2020 -- Source: Scopus |
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