Fibroblast growth factor receptor is a portal of cellular entry for herpes simplex virus type 1 Journal Article
| Authors: | Kaner, R. J.; Baird, A.; Mansukhani, A.; Basilico, C.; Summers, B. D.; Florkiewicz, R. Z.; Hajjar, D. P. |
| Article Title: | Fibroblast growth factor receptor is a portal of cellular entry for herpes simplex virus type 1 |
| Abstract: | Herpes simplex virus type 1 (HSV-1) is a ubiquitous pathogen responsible for considerable morbidity in the general population. The results presented herein establish the basic fibroblast growth factor (FGF) receptor as a means of entry of HSV-1 into vertebrate cells. Inhibitors of basic FGF binding to its receptor and competitive polypeptide antagonists of basic FGF prevented HSV-1 uptake. Chinese hamster ovary (CHO) cells that do not express FGF receptors are resistant to HSV-1 entry; however, HSV-1 uptake is dramatically increased in CHO cells transfected with a complementary DNA encoding a basic FGF receptor. The distribution of this integral membrane protein in vivo may explain the tissue and cell tropism of HSV-1. |
| Keywords: | animal; cell line; transfection; vertebrata; dna; amino acid sequence; molecular sequence data; cell culture; peptide fragments; cell membrane; simplexvirus; adsorption; virus infection; herpes simplex virus 1; herpes; fibroblast growth factor; fibroblast growth factors; heparitin sulfate; receptors, cell surface; cricetinae; cricetulus griseus; binding, competitive; cell receptor; human herpesvirus 1; receptors, fibroblast growth factor; priority journal; article; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; hamsters |
| Journal Title: | Science |
| Volume: | 248 |
| Issue: | 4961 |
| ISSN: | 0036-8075 |
| Publisher: | American Association for the Advancement of Science |
| Date Published: | 1990-06-15 |
| Start Page: | 1410 |
| End Page: | 1413 |
| Language: | English |
| DOI: | 10.1126/science.2162560 |
| PUBMED: | 2162560 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 27 January 2020 -- Source: Scopus |
