Approaches to more effective induction of cytodifferentiation of transformed cells and potential for cancer treatment Conference Paper
| Authors: | Marks, P. A.; Rifkind, R. A. |
| Title: | Approaches to more effective induction of cytodifferentiation of transformed cells and potential for cancer treatment |
| Conference Title: | Annual Meeting of the Japanese Society of Clinical Hematology |
| Abstract: | Conceptually, the use of cytodifferentiation agents to suppress oncogenicity may prove most effective in long-term continuous treatment of patients whose tumors display some inherent expression of differentiated characteristics. This is the case in many pre-malignant lesions. The difficulty in evaluating the therapeutic role for HMBA is often times in separating in vivo cytotoxic from cytodifferentiation effects. Only with further studies will it be determined whether these and other cytodifferentiation agents are therapeutically useful and whether study of the mechanism faction of these agents provides additional understanding of the processes of cellular transformation and differentiation with which they interact. |
| Keywords: | signal transduction; genetics; review; neoplasm; neoplasms; animal; metabolism; vincristine; cell differentiation; drug effect; pathology; tumor cells, cultured; oncogenes; oncogene; cell culture; protein kinase c; phorbol 13 acetate 12 myristate; tetradecanoylphorbol acetate; leukemia, erythroblastic, acute; erythroleukemia; hexamethylenebisacetamide; acetamides; human; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; acetamide derivative |
| Journal Title | [Rinsho Ketsueki] The Japanese Journal of Clinical Hematology |
| Volume: | 31 |
| Issue: | 4 |
| Conference Dates: | 1989 Nov |
| Conference Location: | Nagoya, Japan |
| ISBN: | 0485-1439 |
| Publisher: | Nihon Rinsho Ketsueki Gakkai |
| Date Published: | 1990-01-01 |
| Start Page: | 401 |
| End Page: | 408 |
| Language: | English |
| PUBMED: | 2199696 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Review -- Export Date: 27 January 2020 -- Source: Scopus |
Citation Impact
Related MSK Work