A pilot trial of the daily intraperitoneal administration of recombinant interleukin-2 Journal Article
| Authors: | Markman, M.; Iannotti, N.; Hakes, T.; Reichman, B.; Rubin, S.; Jones, W.; Hoskins, W.; Lewis, J. L. Jr |
| Article Title: | A pilot trial of the daily intraperitoneal administration of recombinant interleukin-2 |
| Abstract: | In an effort to develop a rational and practical intraperitoneal (i.p.) recombinant interleukin-2 (rIL-2) program that could be explored in future studies of combination i.p. biological therapy, a pilot trial of single-agent rIL-2 delivered i.p. as a single daily dose on a 5-times-weekly schedule was initiated. With a daily x 5 dose of 8 x 105 units/m2 rIL-2 (Ro 23-6019) only minimal systemic and local toxicity was encountered. This dose is recommended for future trials of combination i.p. biological therapy employing a daily x 5 schedule. |
| Keywords: | clinical article; fatigue; interleukin 2; ovary carcinoma; recombinant interleukin 2; intraperitoneal drug administration; human; female; article |
| Journal Title: | Regional Cancer Treatment |
| Volume: | 3 |
| Issue: | 1 |
| ISSN: | 0935-0411 |
| Publisher: | Springer |
| Date Published: | 1990-01-01 |
| Start Page: | 44 |
| End Page: | 46 |
| Language: | English |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 27 January 2020 -- Source: Scopus |
