Re-186(Sn) HEDP for treatment of painful osseous metastases: Initial clinical experience in 20 patients with hormone-resistant prostate cancer Journal Article

  


Authors: Maxon, H. R. 3rd; Schroder, L. E.; Thomas, S. R.; Hertzberg, V. S.; Deutsch, E. A.; Scher, H. I.; Samaratunga, R. C.; Libson, K. F.; Williams, C. C.; Moulton, J. S.; Schneider, H. J.
Article Title: Re-186(Sn) HEDP for treatment of painful osseous metastases: Initial clinical experience in 20 patients with hormone-resistant prostate cancer
Abstract: Rhenium-186(tin) hydroxyethylidene diphosphonate (HEDP) is a new radiopharmaceutical that localizes in areas of osseous metastases in a manner similar to that of standard bone-scanning agents. It also emits beta particles with sufficient energy to be therapeutically useful. A single intravenous injection of about 33mCi (1,221 MBq) was given to each of 20 elderly patients with advanced skeletal metastases from honnonally resistant prostate cancer. Prompt, significant relief of pain occurred 80% of the time with no significant side effects and only minimal, transient marrow toxicity. Re-186(Sn) HEDP appears to be a useful new agent for the palliation of painful osseous metastases in prostate cancer.
Keywords: adult; aged; bone neoplasms; unclassified drug; bone metastasis; methodology; adenocarcinoma; palliative care; quality of life; pain; radiotherapy dosage; estrogens; prostatic neoplasms; radioisotope; radioisotopes; analgesia; organometallic compounds; radioisotope therapy; intravenous drug administration; prostate carcinoma; rhenium; etidronic acid; tin; human; male; priority journal; article; support, u.s. gov't, p.h.s.; support, u.s. gov't, non-p.h.s.; prostate, neoplasms, 844.32; bone neoplasms, secondary, 30.33,40.33; bone neoplasms, therapeutic radiology, 40.1299; radionuclides, therapeutic, 40.1299; etidronate tin re 186
Journal Title: Radiology
Volume: 176
Issue: 1
ISSN: 0033-8419
Publisher: Radiological Society of North America, Inc.  
Date Published: 1990-07-01
Start Page: 155
End Page: 159
Language: English
DOI: 10.1148/radiology.176.1.1693784
PUBMED: 1693784
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0025358769&doi=10.1148%2fradiology.176.1.1693784&partnerID=40&md5=aa36d45e403f70501426a05a3d24d8ba
Notes: Article -- Export Date: 27 January 2020 -- Source: Scopus
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  1. Howard Scher
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