Expression of transforming growth factor alpha in human gliomas Journal Article
| Authors: | Schlegel, U.; Moots, P. L.; Rosenblum, M. K.; Thaler, H. T.; Furneaux, H. M. |
| Article Title: | Expression of transforming growth factor alpha in human gliomas |
| Abstract: | Expression of transforming growth factor alpha (TGF alpha) is frequently associated with the development of human and animal tumors. Using a sensitive immunohistochemical assay, which can be applied on formalin-fixed, paraffin-embedded tissue, we have examined the expression of TGF alpha in 71 human gliomas (63 untreated and 8 recurrent tumors). Tumors were graded by a 3-grade-system:grade I = low grade gliomas, grade II = anaplastic gliomas and grade III = glioblastomas. A strong positive correlation between tumor grade and extent of TGF alpha expression was found (P < 0.0001). Polymerase chain reaction reaction (PCR) was used to amplify the fourth exon of the TGF alpha gene of 8 glioma DNA specimens and increasing amounts of normal human DNA, which served as a standard. No amplication of the TGF alpha gene copy number in tumors could be detected. |
| Keywords: | immunohistochemistry; human tissue; glioma; brain neoplasms; polymerase chain reaction; gene amplification; gene expression; animalia; gene expression regulation, neoplastic; molecular sequence data; dna, neoplasm; base sequence; transforming growth factor alpha; human; priority journal; article; support, non-u.s. gov't |
| Journal Title: | Oncogene |
| Volume: | 5 |
| Issue: | 12 |
| ISSN: | 0950-9232 |
| Publisher: | Nature Publishing Group |
| Date Published: | 1990-12-01 |
| Start Page: | 1839 |
| End Page: | 1842 |
| Language: | English |
| PUBMED: | 2284103 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 27 January 2020 -- Source: Scopus |
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