A and T homopolymeric stretches mediate a DNA inversion in Plasmodium falciparum which results in loss of gene expression Journal Article

   


Authors: Pologe, L. G.; De Bruin, D.; Ravetch, J. V.
Article Title: A and T homopolymeric stretches mediate a DNA inversion in Plasmodium falciparum which results in loss of gene expression
Abstract: Ring-infected erythrocyte surface antigen-negative isolates of Plasmodium falciparum demonstrate a complex DNA rearrangement with inversion of 5' coding sequences, deletion of upstream and flanking sequences, and healing of the truncated chromosome by telomere addition. An inversion intermediate that results in the telomeric gene structure for RESA has been identified in the pathway. This inversion creates a mitotically stable substrate for the sequence-specific addition of telomere repeats at the deletion breakpoint.
Keywords: nonhuman; telomere; gene expression; gene rearrangement; plasmodium falciparum; protozoa; protozoon; priority journal; article; gene inversion
Journal Title: Molecular and Cellular Biology
Volume: 10
Issue: 6
ISSN: 0270-7306
Publisher: American Society for Microbiology  
Date Published: 1990-06-01
Start Page: 3243
End Page: 3246
Language: English
DOI: 10.1128/mcb.10.6.3243
PUBMED: 2188111
PROVIDER: scopus
PMCID: PMC360690
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0025283656&doi=10.1128%2fMCB.10.6.3243&partnerID=40&md5=b99f5f792825d67a6f833fa4f1757ee0
Notes: Article -- Export Date: 27 January 2020 -- Source: Scopus
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MSK Authors
  1. Jeffrey V. Ravetch
    72 Ravetch
  2. Derik de Bruin
    13 de Bruin
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